Home ／About／Faculty／Professor／Dr. Jentaie Shiea

Dr. Jentaie Shiea
Dr. Jentaie Shiea Professor
Research Areas Organic and Biomedical Mass Spectrometry, Ambient Ionization Mass Spectrometry
highest education Ph. D., Montana State University, USA
Research room C3018
laboratory C2004
phone (07)5252000 分機3933
E-mail jetea@mail.nsysu.edu.tw
web https://sites.google.com/view/lab-of-obms
 Personal profile

學歷Education

PhD, Montana State University (1988-1991)

Master, Montana State University (1985-1988)

Bachelor, National Chung Hsing University (1977-1981)

經歷Experience

Professor, National Sun Yat-sen University, Taiwan (1998-present)
Associate Professor, National Sun Yat-sen University, Taiwan (1991-1998)
Visiting Professor, UCLA (2004-2005)
Visiting Associate Professor, Montana State University (1995-1996)
Postdoctoral researcher, Pennsylvania State University (1991-1991)
Director, The Rapid Screen Research Center, National Sun Yat-sen University, Taiwan(2018-present)

MOST Outstanding Research Award (2020)
MOST Future Tech Demo and Breakthrough Award (2019)

1.低溫大氣壓游離法 (Low Temperature Ionization)

2. 直接電噴灑游離探針 (Direct Electrospray Probe, DEP)

3.瞬間熱裂解 (Pyrolysis, Py) 結合融合微滴電噴灑游離法 (Fused-droplet electrospray ionization, FD-ESI)

4.電噴灑輔助雷射脫附游離法 (Electrospray-Assisted Laser Desorption Ionization, ELDI)

5.薄層層析法 (Thin Layer Chromatography, TLC) 結合電噴灑輔助雷射脫附游離法 (Electrospray-Assisted Laser Desorption Ionization, ELDI)

6.雷射誘導聲波脫附 (Laser-Induced Acoustic Desorption, LIAD) 結合融合微滴電噴灑游離法 (Fused-Droplet Electrospray Ionization, FD-ESI)

7.熱脫附電噴灑游離質譜法 (Thermal Desorption Electrospray Ionization, TD-ESI)

8.雙電噴灑及大氣壓化學游離法 (Dual Electrospray and Atmospheric Pressure Chemical Ionization)

9.火焰誘導大氣壓化學游離法 (Flame-Induced Atmospheric Pressure Chemical Ionization, FAPCI)

10.多通道電噴灑游離法 (Multiple Channel Electrospray Ionization)

11.旋轉式電噴灑游離法 (Rotating Electrospray Ionization, RESI)

12.鋸齒狀薄層層析法結合電噴灑游離質譜法 (Sawtooth TLC-ESI/MS)

13.微固相萃結合電灑游離質譜法取法 (Solid Phase Microextraction-Thermal-Desorption Electrospray Ionization Mass Spectrometry, SPME-TD-ESI/MS)

    著作Works
  1. Cho, Y. T.; Su, H.; Huang, T. L.; Chen, H. C.; Wu, W. J.; Wu, P. C.; Wu, D. C. ; Shiea, J.,"Matrix-assisted Laser Desorption Ionization/time-of-flight Mass Spectrometry for Clinical Diagnosis” Clin. Chim. Acta 2013, 415, 266-275. (Invited Review Article, Citation: 42)
  2. Cheng, S.C.; Huang,  M. Z.; Shiea, J.,"Thin Layer Chromatography/Mass Spectrometry”  J. Chromatogr. A, 2011, 1218, 2700-2711. (Invited Review Article, Citation: 104)
  3. Huang, M. Z.; Cho, Y. T.; Cheng, S. C.; Shiea, J.,"Ambient Ionization Mass Spectrometry - A Tutorial” Anal. Chim. Acta 2011, 702, 1-15. (Invited Review Article, Citation: 257)
  4. Huang, M. Z.; Yuan, C. H.; Cheng, S. C.; Cho, Y. T.; Shiea, J.,"Ambient Ionization Mass Spectrometry” Annual Review Analytical Chemistry, 2010, 3, 43-65. (Citation: 252)
  5. Shiea, J.; Huang, M. Z.; Hsu, H. J.; Lee, C. Y.; Yuan, C. H.; Beech, I.; Sunner, J., Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids. Rapid Commun. Mass Spectrom. 2005, 19(24), 3701-3704. (Citation: 478)
  6. Chang, D. Y.; Lee, C. C.; Shiea, J., Detecting Large Biomolecules from High-salt Solutions by Fused-droplet Electrospray Ionization Mass Spectrometry. Anal. Chem. 2002, 74(11), 2465-2469. (Citation: 131)
  7. Yuan, C. H.; Shiea, J., Sequential Electrospray Analysis Using Sharp-tip Channels Fabricated on a Plastic Chip. Anal. Chem. 2001, 73(6), 1080-1083. (Citation: 142)
  8. Shiea, J.; Shimma S.; Lai, C. C., A Special Issue for 2018 Mass Spectrometry for Clinical Diagnosis. Rapid Commun. Mass Spectrom. 2020, doi: 10.1002/rcm.8702.
  9. Su, H.; Lin, J. Y.; Shiea, J.,"In-situ Detection of Chemical Compounds Using Ambient Ionization Mass Spectrometry”. 2019, 57, 42-51.
  10. Shiea, J., A Special Issue for 2017 Mass Spectrometry for Clinical Diagnosis. J. Food Drug Anal. (Taiwan). 2019, 27, 375-614.
  11. Cheng, S.; Shiea, J.,"Rapid Characterization of toxic compounds with Ambient Mass Spectrometric system”. SciTech Reports., 2018.
  12. Liao, P. C; Shiea, J., A Special Issue for The 13th Annual Conference of the Taiwan Society for Mass Spectrometry. Mass Spectrom. (Tokyo) . 2017, 6(2): K0010.
  13. Cheng, S.; Su, H.; Lee, R. H.; Cai, Y. D.; Lee, C. W.; Shiea, J.,"Rapid Characterization of Pesticides and Drugs in Biofluids and on  Solid Samples with Thermal Desorption Electrospray Ionization Mass Spectrometry”. Taiwan I. Forensic Medicine, 2016, 8(2), 28-41.
  14. Cheng, S.; Shiea, J.,"Interfacing TLC with Laser-Based Ambient Mass Spectrometry”. Planar. Chromatogr. Mass Spectrom., 2015, 110, 105-118.
  15. Su, H.; Shiea, J.,"Laser-Based Molecular Imaging Mass Spectrometry ”. Instrum. Today, 2015, 203, 7-16.
  16. Huang, M. Z.; Jhang, S. S.; Shiea, J.,"Electrospray Laser Desorption Ionization (ELDI) Mass Spectrometry for Molecular Imaging of Small Molecules on Tissues”. Mass Spectrom. Imaging of Small Molecules, 2015, 1203, 107-116.
  17. Cho, Y. T.; Su, H.; Wu, W. J.; Wu, D. C.; Hou, M. F.; Kuo, C. H.; Shiea, J.,"Biomarker Characterization by MALDI-TOF/MS”. Adv. Clin. Chem. 2015, 69, 209-254.
  18. Huang, M. Z.; Jhang, S. S.; Chan, Y. T.; Cheng, S. C.; Cheng, C. N.; Shiea, J.,"Electrospray Laser Desorption Ionization Mass Spectrometry”. Ambient Ionization Mass Spectrom., 2014, 372-388.
  19. Cheng, S.; Shiea, J.,"Advanced Spectroscopic Detectors for Identification and Quantification: Mass Spectrometry”. Instrum. Thin-Layer Chromatogr., 2014, 249-278.
  20. Li, L. J.; Liao, P. C.; Shiea, J., Mass Spectrometry for Clinical Diagnosis Preface. Clin. Chim. Acta 2013, 420, 1-3.
  21. Shiea, J.; Chou, C. C.;"Mobile Ambient Mass Spectroscopy” Instrum. Today, 2012, 187, 3-9.
  22. Cheng, C. N.; Lai, J. H.; Huang, M. Z.; Oung, J. N.; Shiea, J.;"Analysis of Polar Components in Crude Oil by Ambient Mass Spectrometry" in "Crude Oil Emulsions – Composition Stability and Characterization" (ed. M. El-Sayed Abdul-Raouf). Intech, 2012, 6, 107-120.
  23. Jeng, J. Y., Jiang, Z. H., Cho, Y. T., Su, H., Lee, C. W., Shiea, J.; Obtaining Molecular Imagings of Pesticide Residues on Strawberry Surfaces with Probe Sampling Followed by Ambient Ionization Mass Spectrometric Analysis. J. Mass Spec. 2020, doi: 10.1002/jms.4644. (Special issue)
  24. Wang, Y. L.; Jin, Q.; Shiea, J.; Sun, W. J.; Wire Desorption Combined With Electrospray Ionization Mass Spectrometry: Direct Analysis of Small Organic and Large Biological Compounds.  J. Am. Soc. Mass Spectrom. 2020, doi: 10.1021/jasms.0c00107.
  25. Chan, H. C.; Chan, H. C.; Liang, H. J.; Lee, H. C.; Su, H.; Lee, A. S.; Shiea, J.; Tsai, W. C.; Ou, T. T.; Wu, C. C.; Chu, C. S.; Dixon, R. A.; Ke, L. Y.; Yen, J. H.; Chen, C. H., Role of Low-density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2020, doi: 10.1002/art.41213
  26. Wang, C. H.; Su, H.; Chou, J. H.; Lin, J. Y.; Huang, M. Z.; Lee, C. W.; Shiea, J., Multiple Solid Phase Microextraction Combined with Ambient Mass Spectrometry for Rapid and Sensitive Detection of Trace Chemical Compounds in Aqueous Solution. Anal. Chim. Acta 2020, 1107, 101-106.
  27. Su, H.; Yeh, I. J.; Wu, Y. H.; J, Z. H.; Shiea, J.; Lee, C. W., Rapid identification of organophosphorus pesticides on contaminated skin and confirmation of adequate decontamination by ambient mass spectrometry in emergency settings. Rapid Commun. Mass Spectrom. 2020, doi: 10.1002/rcm.8562. (Special issue)
  28. Su, H.; Huang, Y. J.; Huang, M. Z.; Lee, Y. T.; Chen, S. C.; Hung, C. H.; Kuo, C. H.; Wu, M. T.; Shiea, J., Using Ambient Mass Spectrometry to Explore the Origins of Phthalate Contamination in a Mass Spectrometry Laboratory. Anal. Chim. Acta 2020, 1105, 128-138.
  29. Cheng, S. C.; Lee, R. H.; Jeng, J. Y.; Lee, C. W.; Shiea, J., Fast screening of trace multiresidue pesticides on fruit and vegetable surfaces using ambient ionization tandem mass spectrometry. Anal. Chim. Acta 2020, 1102, 63-71.
  30. Shiea, J.; Bhat, S. M.; Su, H.; Ponnusamy, V. K.; Lee, C. W.; Wang, C. H., Rapid Quantification of Acetaminophen in Plasma Using Solid Phase Microextraction Coupled with Thermal Desorption-Electrospray Ionization/Mass Spectrometry. Rapid Commun. Mass Spectrom. 2020, doi: 10.1002/rcm.8564. (Special issue)
  31. Su, H.; Lin Y. P.; Yang, S. C.; Kuo, C. H.; Wu, D. C.; Shiea, J.; Lee, C. W., Rapid detection of non-volatile household pesticides in drained gastric juice by ambient mass spectrometry for emergency management. Anal. Chim. Acta 2019, 1066, 69-78.
  32. Sambandan, E.; Kathavarayan, T.; Sellappan, S.; Shiea, J.; Ponnusamy, V. K., Identification and characterization of unknown degradation impurities in beclomethasone dipropionate cream formulation using HPLC, ESI-MS and NMR. J. Pharm. Biomed. Anal. 2019, 167, 123-131.
  33. Cheng, S. C.; Tsai, Y. D.; Lee, C. W.; Chen, B. H.; Shiea, J., Direct and Rapid Characterization of Illicit Drugs in Adulterated Samples Using Thermal Desorption Electrospray Ionization Mass Spectrometry. J. Food Drug Anal. 2019, 27, 451-459. (Special issue)
  34. Su, H.; Liu, K. T.; Chen, B. H.; Lin, Y. P.; Jiang, Y. M.; Tsai, Y. H.; Chang, F. R.; Shiea, J.; Lee, C. W., Rapid Identification of Herbal Toxins Using Electrospray Laser Desorption Ionization Mass Spectrometry for Emergency Care. J. Food Drug Anal. 2019, 27, 415-427. (Cover image of special issue)
  35. Cheng, S. C.; Bhat, S. M.; Lee, C. W.; Shiea, J., Simple Interface for Scanning Chemical Compounds on Developed Thin Layer Chromatography Plates Using Electrospray Ionization Mass Spectrometry. Anal. Chim. Acta 2019, 1049, 1-9.
    專利Patents