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林伯樵
林伯樵 教授兼教務長
研究領域 有機合成及合成方法開發(有機探針、有機醫學材料)
最高學歷 中央研究院國際院生學程(TIGP)暨國立清華大學化學系
研究室 理4023
實驗室 理4023
電話 (07)5252000 分機3913
E-mail pclin@mail.nsysu.edu.tw
個人網頁 https://pochiaolab.wixsite.com/pochiao
 個人簡介

學歷Education

國立中山大學化學系副教授

美國科羅拉多大學博爾德分校化學與生物醫學工程系訪問學者

國立中山大學化學系助理教授

台灣中央研究院化學研究所，研究助理(國防服務)

經歷Experience

2019 國立中山大學教學績優獎

2019國立中山大學理學院教學績優獎

2019中國化學會傑出青年化學家獎章

2019亞洲尖端化學巡迴講座Lectureship Award (香港)

2018亞洲尖端化學巡迴講座Lectureship Award (中國)

2015國立中山大學理學院教學績優獎2015國立中山大學理學院教學績優獎

2015年被選為英國皇家化學會分析方法研究新秀獎

2014亞洲尖端化學有機化學巡迴講演獎

2014亞洲尖端化學巡迴講座Lectureship Award (韓國)

2014亞洲尖端化學巡迴講座Lectureship Award (新加坡)

2014年國立中山大學特聘年輕學者

2009年Max-Planck研究獎，Max-Planck研究所，德國

2008年中國化學學會傑出論文獎

2008年台灣國際研究生課程(TIGP)會議資助

2003年中國化學學會論文獎

    著作Works
  1. C.- H. Chou, C.- Y. Wu, C.- L. Chen, J.- Q Zhou, Y.- C. Kao, H.-Y. Chen, P.- C. Lin* "In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence" Chem. Comm. 2020, Advance Article, DOI : 10.1039/ d0cc03090b html
  2. J.-G. You, D.-Y. Jin, W.-B. Tseng, W.-L. T*, P.-C. Lin* "Gold(I)‐Thiolate Oligomers for Catalytic Hydrogenation of Nitroaromatics in Aqueous and Organic Medium" ChemCatChem. 2020, 12, 4558-4567 html
  3. H.-C. Tu, Y.-P. Lee, X.-Y. Liu, C.-F. Chang, and P.-C. Lin* "Direct Screening of Glycan Patterns from Human Sera: A Selective Glycoprotein Microarray Strategy" ACS Appl. Bio Mater. 2019, 2, 1286.
  4. Y.-W. Luo, C.-H. Chou, P.-C. Lin,* and C.-M. Chiang* " Photochemical Synthesis of Azoarenes from Aryl Azides on Cu(100): A Mechanism Unraveled" J. Phy. Chem. C 2019, 123, 12195.
  5. S.-C. Tang, H. Ma, H.-C. Tu, H.-R. Wang, P. C. Lin* and Kristi S. Anseth* “Adaptable Fast Relaxing Boronate - Based Hydrogels for Probing Cell Matrix Interactions” Adv. Science 2018, 1800638. html (SCI impact factor:12.441; 5-Year IF:12.551, ranking: 13/171 (Q1) in chemistry, multidisciplinary)
  6. K.-K. Yu, W.-B. Tseng, M.-J. Wu, A. S. K. K. Alagarsamy, W.-L. Tseng*, P.-C. Lin* “Polyadenosine- based fluorescent probe for reversible pH sensing based on protonated adenine-adenine base pairs: Applications to sensing of enzymesubstrate system and enzymatic logic gates” Sens. actuators. B Chem. 2018, 273, 681–688. html (SCI impact factor:5.667; 5-Year IF:5.118, ranking: 2/61 (Q1) in instrument & instrumentation)
  7. C.-H. Chou, P.-C. Lin* “Glycan-Directed Grafting-from Polymerization of Immunoglobulin G: Site-Selectively Modified IgG-Polymer Conjugates with Preserved Biological Activity” Biomacromolecules, 2018, 19, 3086–3095. html (SCI impact factor:5.738; 5-Year IF:5.941, ranking: 6/87 (Q1) in polymer science)
  8. C.-H. Chou, B. Rajagopal, C.-F. Liang, K.-L. Chen, D.-Y. Jin, H.-Y. Chen*, H.-C. Tu, Y.-Y. Shen, P.-C. Lin* “Synthesis and Photophysical Characterization of 2,3-Dihydroquinolin-4-imines: New Fluorophores with Color-Tailored Emission.” Chem. Eur. J., 2018, 24, 1112–1120.html (SCI impact factor:5.160; 5-Year IF:4.950, ranking: 37/171 (Q1) in Chemistry, multidisciplinary)
  9. C.‐C. Chen, S.‐F. Wang, Y.‐Y. Su, Y. A. Lin, P.‐C. Lin* “Copper(I)‐Mediated Denitrogenative Macrocyclization for the Synthesis of Cyclic α3β‐Tetrapeptide Analogues” Chem. Asian J., 2017, 12, 1326–1337 html (SCI impact factor:3.692; 5-Year IF:3.497, ranking: 51/171 (Q1) in Chemistry, multidisciplinary)
  10. C.-H. Chou, Y.-Y. Chen, B. Rajagopal, H.-C. Tu, K.-L. Chen, S.-F. Wang, C.-F. Liang, Y.-C. Tyan, and P.-C. Lin* “Thermally Induced Denitrogenative Annulation for the Synthesis of Dihydroquinolinimines and Chroman-4-imines” Chem. Asian J., 2016, 11, 757–765.html (SCI impact factor:3.692; 5-Year IF:3.497, ranking : 51/171 (Q1) in Chemistry, multidisciplinary)
  11. Y.-Y. Chen, K.-L. Chen, Y.-C. Tyan, C.-F. Liang, P.-C. Lin* “Synthesis of substituted 3-methylene-2,3-dihydrobenzofurans and 3-methylbenzofurans by rhodium (II)-catalyzed annulation” Tetrahedron, 2015, 71, 6210-6218. html (SCI impact factor:2.377; 5-Year IF:2.255, ranking : 23/57 (Q2) in Chemistry, organic)
  12. C.-C. Chen, P.-C. Lin* “Monitoring of chemical transformations by mass spectrometry.” Anal. Methods, 2015, 7, 6947–6959. html (SCI impact factor:2.073; 5-Year IF:2.000 , ranking: 52/133 (Q2) in food science & technology)
  13. B. Rajagopal, C.-H. Chou, C.-C. Chung, P.-C. Lin* “Synthesis of Substituted 3-Indolylimines and Indole-3-carboxaldehydes by Rhodium (II)-Catalyzed Annulation.” Org. Lett. 2014, 16, 3752–3755. html (SCI impact factor:6.492; 5-Year IF:5.778, ranking: 3/57 (Q1) in chemistry, organic)
  14. B. Rajagopal, Y.-Y. Chen, C.-C. Chen, X.-Y. Liu, H.-R. Wang, P.-C. Lin* “Cu(I)-Catalyzed Synthesis of Dihydropyrimidin-4-ones toward the Preparation of β- and β3-Amino Acid Analogues” J. Org. Chem. 2014, 79, 1254–1264. html (SCI impact factor:4.805; 5-Year IF:4.313, ranking: 9/57 (Q1) in chemistry, organic)
  15. Y.-L. Yang, Y.-P. L., Y.-L. Yang, P.-C. Lin* “Traceless Labeling of Glycoproteins and Its Application to the Study of Glycoprotein-protein Interact” ACS Chem. Biol. 2014, 9, 390-397. html (SCI impact factor:4.592; 5-Year IF:4.794, ranking: 57/292 (Q1) in biochemistry & molecular biology)
  16. C.-C. Chen, B. Rajagopal, X.-Y. Liu, K.-L. Chen, Y.-C. Tyan, F. Lin, P.-C. Lin* “A mild removal of Fmoc group using sodium azide” Amino Acids, 2014, 46, 367–374.html ; 5-Year 2.906SCI impact factor:(:2.946, ranking:148/292 (Q3) in biochemistry & molecular biology)IF
  17. S. Hsieh*, S.-L. Hsieh, C.-W. Hsieh, P.-C. Lin, C.-H. Wu “Label-free glucose detection using cantilever sensor technology based on gravimetric detection principles” J. Anal. Methods. Chem. 2013, Article ID 687265.html (SCI impact factor:1.262; 5-Year IF:1.722, ranking:75/128 (Q3) in engineering, civil)
  18. Y.-W. Lu, C.-W. Chien, P.-C. Lin, L.-D. Huang, C.-Y. Chen, S.-W. Wu, C.-L. Han, K.-H. Khoo, C.-C Lin.*, Y.-J. Chen* “BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichmentof Glycoproteins” Anal. Chem. 2013, 85, 8268-8276. html (SCI impact factor:6.042; 5-Year IF:6.035, ranking:4/80 (Q1) in chemistry, analytical)
  19. C.-C. Chen, Y.-L. Yang, C.-L. Ou, C.-H. Chou, C.-C. Liaw, P.-C. Lin* “Direct Monitoring of Chemical Transformations by Combining Thin Layer Chromatography with Nanoparticle-assisted Laser Desorption /Ionization Mass Spectrometry” Analyst, 2013, 138, 1379–1385. html SCI impact factor:3.864; 5-Year IF:3.791, ranking:11/80 (Q1) in chemistry, analytical)
  20. Y.-L. Yang, B. Rajagopal, C.-F. Liang, C.-C. Chen, H.-P. Lai, C.-H. Chou, Y.-P. Lee, Y.-L. Yang, J.-W. Zeng, C.-L. Ou, P.-C. Lin* “Chemoselective Synthesis of Aryl Carboxamido Sulfonic Acid Derivatives” Tetrahedron, 2013, 69, 2640–2646.html (SCI impact factor:2.377; 5-Year IF:2.255, ranking: 23/57 (Q2) in chemistry, organic)
  21. P.-C. Lin*, C.-C. Yu, H.-T. Wu, Y.-W. Lu, C.-L. Han, A.-K. Su, Y.-J. Chen*, C.-C. Lin* “A Chemically Functionalized Magnetic Nanoplatform for Rapid and Specific Biomolecular Recognition and Separation” Biomacromolecules, 2013, 14, 160-168. html (SCI impact factor:5.738; 5-Year IF:5.941, ranking: 6/87 (Q1) in polymer science)
  22. L. Yi, Y.-X. Chen, P.-C. Lin, Schröder H, C.-M. Niemeyer, Y.-W. Wu, R.-S. Goody, G. Triola*, H. Waldmann* “Direct immobilization of oxyamine-modified proteins from cell lysates.” Chem. Commun. 2012, 48, 10829-10831. html
  23. R.-P. Obena, P.-C. Lin, Y.-W. Lu, I.-C. Li, F. Del Mundo, S. D. Arco, G.M. Nuesca, C.-C. Lin*, Y.-J. Chen, “Iron oxide nanomatrix facilitating metal ionization in matrix-assisted laser desorption/ionization mass spectrometry.” Anal. Chem. 2011, 83, 9337–9343. html
  24. H.-T. Wu, C.-C. Hsu, C.-F. Tsai, P.-C. Lin, C.-C. Lin* and Y.-J. Chen,” Nanoprobe based Immobilized Metal Affinity Chromatography for Enhanced Enrichment of Multiply Phosphorylated Peptides” Proteomics, 2011, 11, 2639–2653. html
  25. W.-C. Chen, P.-C. Lin, C.-H. Chen, C.-T. Chen “Modulation of Photoswitching Profiles by 10,11-Dialkoxymethyl Substituents in C2-Symmetric Dibenzosuberane-Based Helicenes” Chem. Eur. J., 2010, 43, 12822–12830. html
  26. M.-C. Tseng, R. Obena, Y.-W. Lu, P.-C. Lin, P.-Y. Lin, Y.-S. Yen, J.-T. Lin, L.-D. Huang, K.-L. Lu, L.-L. Lai, C.-C. Lin, Y.-J. Chen “Dihydrobenzoic Acid Modified Nanoparticle as a MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures” J. Am. Soc. Mass Spectrom, 2010, 11, 1930–1939.html
  27. D. Weinrich, P.-C. Lin, P. Jonkheijm, H. Schröder, C. M. Niemeyer, K. Alexandrov, H. Waldmann. “Oriented Immobilization of Farnesylated Proteins by Thiol-Ene Reaction” Angew. Chem. Int. Ed. 2010, 49,1252–1257. html
  28. P.-C. Lin, D. Weinrich, H. Waldmann “Protein Biochips: Oriented Surface Immobilization of Proteins” Marcromol. Chem. Phys. 2010, 211, 136–144. hmtl
  29. P.-C. Lin, A. K. Adak, S.-H. Ueng, L.-D. Huang, K.-T. Huang, C.-C. Lin*, “ DAST-Mediated Regioselective Anomeric Group Migration in Saccharides” J. Org. Chem. 2009, 74, 4041–4048.hmtl
  30. P.-C. Lin, S.-H. Chen, M.-L. Chen, A. Kumar Adak, Y.-J. Chen* and C.-C. Lin*, “Fabrication of Oriented Antibody-Conjugated Magnetic Nanoprobes and Their Immunoaffinity Application” Anal. Chem. 2009, 81, 8774–8782 html
  31. P.-C. Lin, H.-T. Wu, K.-Y. Wang, Y.-J. Chen, C.-C. Lin, “Development and Application of Functionalized Nanoparticles on Mass Spectrometry for the Analysis of Target Biomolecules” Instruments Today, 2008, 29, 68. (in Taiwan) html
  32. K.-Y. Wang, S.-A. Chuang, P.-C. Lin, S.-H. Chen, L.-S. Huang, C.-C. Lin, and Y.-J. Chen* “Multiplexed Immunoassay: Quantitation and Profiling of Serum Biomarkers Using Magnetic Nanoprobes and MALDI-TOF MS” Anal. Chem. 2008, 80, 6159–6167. html
  33. P.-H. Shih, J.-Y. Shiu, P.-C. Lin, C.-C. Lin, T. Veres, P. Chen “On chip sorting of bacterial cells using sugar-encapsulated magnetic nanoparticles” J. Appl. Phys. 2008, 103, 07A316. html
  34. C.-C. Yu, P.-C. Lin, C.-C. Lin* “Site-specific CMP-sialic acid synthetase Immobilized Magnetic Nanoparticle in the synthesis of CMP-sialic acid” Chem. Commun. 2008, 0, 1308–1310. html
  35. T.-C. Chiu, L.-S. Huang, P.-C. Lin, Y.-C. Chen, Y.-J. Chen, C.-C. Lin, H.-T. Chang, “Nanomaterial Based Affinity Matrix-assisted Laser Desorption/Ionization Mass Spectrometry for Biomolecules and Pathogenic Bacteria” Recent patents on Nanotechnology, 2007, 1, 99–111. html
  36. P.-C. Lin, S.-H. Ueng, S.-C. Yu, M.-D. Jan, A. K. Adak, C.-C. Yu, C.-C. Lin* “Surface Modification of Magnetic Nanoparticle via Cu(I)-Catalyzed Alkyne-azide [2 + 3] Cycloaddition” Org. Lett. 2007, 9, 2131–2134. html
  37. P.-C. Lin, M.-C. Tseng, A.-K. Su, Y.-J. Chen*, C.-C. Lin* “Functionalized Magnetic Nanoparticles for Small-Molecule Isolation, Identification, and Quantification” Anal. Chem. 2007, 79, 3401–3408. html
  38. P.-C. Lin, S.-H. Ueng, M.-C. Tseng, J.-L. Ko, K.-T. Huang, S.-C. Yu, A. K. Adak, Y.-J. Chen, C.-C. Lin,* “Site-Specific Protein Modification through CuI-Catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication“ Angew. Chem. Int. Ed. 2006, 45, 4286–4290. html
  39. P.-C. Lin, P.-H. Chou, S.-H. Chen, H.-K. Liao, K.-Y. Wang, Y.-J. Chen, C.-C. Lin* “Ethylene Glycol-Protected Magnetic Nanoparticles for a Multiplexed Immunoassay in Human Plasma” Small, 2006, 2,485–489. html
  40. P.-H. Chou, S.-H. Chen, H.-K. Liao, P.-C. Lin, G.-R. Her, Alan C.-Y. Lai, J.-H. Chen, C.-C. Lin*, Y.-J. Chen* “Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma” Anal. Chem. 2005, 77, 5990–5997. html
  41. Po-chiao Lin, Yung-lin Yang, Yen-pin Lee (2016): Method of traceless labeling glycoproteins on surface and application thereof, U. S. Appl. Publ. US20160123988A1
  42. Po-Chiao Lin, Chun-Chi Chen (2013): Method for detecting by thin-layer chromatograph mass spectrometry, Taiwan (R.O.C.) Appl. Publ. TW201443432A
  43. Y.-J. Chen, P.-C. Lin, C.-C. Lin, S.-H. Chen, P.-H. Chou, H.-K. Liao (2007): Mass spectrometric analysis of ligand conjugated magnetic nanoparticles, U. S. Appl. Publ. US20070054407
  44. L.-S. Huang, Y.-Y. Chien, S.-H. Chen, P.-C. Lin, K.-Y. Wang, P.-H. Chou, C.-C. Lin, and Y.-J.Chen,“Nanoprobe-based Affinity Mass Spectrometry for Cancer Marker Protein Profiling”inNanomaterials for Cancer Diagnosis; Eds: Challa S. S. R. Wiley-VCH, 2007
  45. P.-C. Lin, A. Kumar Adak, and C.-C. Lin*,“Fabrication and applications of glyconanomaterials.” inThe Molecular Immunology of Complex Carbohydrates-3; Eds: Albert M. Wu, Kluwer Academia/Plenum Publishers, 2011
  46. Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chien-Hui Lai, Po-Chiao Lin,* Chun-Cheng Lin,*Functionalized glyconanoparticles for the study of glycobiology” in Glyco-nanotechnology as a bridge tonew medicines, ACS Symposium Series 1091, 2011, chapter 2, p15-36.
    專利Patents