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/ Members /

Faculty
Contract-employed Professor
Adjunct Professor
Emeritus Chair Professor
Retired Professor
Staff

Chi-Wi Ong

  • Research Areas: Design and Development of Discotic Liquid Crystals and Related Materials, Anticancer Drug Design, Organic Synthesis
  • Highest eduction: Ph.D. in Chemistry, University of Cambridge, UK
  • Research room: CH3019
  • Laboratory: CH6014
  • Phone: (07)5252000 ext. 3923
  • E-mail: cong@mail.nsysu.edu.tw
  • Web: https://chem2.nsysu.edu.tw/var/file/180/1180/img/780/cw_ong_c..htm

/ Education /

Ph.D. in Chemistry, University of Cambridge, UK (1982)
B.Sc. in Chemistry, University of Liverpool, UK (1979)

/ Experience /

Visiting Professor, Universiti Teknologi Malaysia (1995)
Professor, Department of Chemistry, National Sun Yat-Sen University (1987)
Associate Professor, Department of Chemistry, National Sun Yat-Sen University (1983)
Postdoctoral Research, Cancer Research Center, University of Alberta, Canada (1982)
Permanent Pfeiffer Fellow, Girton College, University of Cambridge
Our lab primarily focuses on the application of organometallic compounds in organic synthesis and the investigation of reaction mechanisms, particularly with iron tricarbonyl complexes of cyclopropenyl (1,3-cyclohexadiene). In fundamental research, we aim to understand the role of substituents on tricarbonyl iron complexes and their effects on reactivity, regioselectivity, and stereochemistry. We also seek to develop new synthetic methods to obtain high-purity photochemically active tricarbonyl iron complexes and explore new synthetic applications.

Another major research direction lies in bioorganic chemistry, especially in drug design and mechanism studies, such as those involving saframycin and bleomycin. Given the severe side effects of many natural anticancer drugs, our goal is to design a new generation of drugs with high anticancer efficacy and lower side effects by understanding the reaction mechanisms of known anticancer agents.

In materials science, discotic liquid crystals (DLCs) are a class of materials with a rigid aromatic core and branched side chains that self-organize into columnar structures. These unique properties have a wide range of potential applications. Our research focuses on the rapid and efficient synthesis of new discotic liquid crystals based on a hexakis-substituted triphenylene (HAT) core and exploring their applications.

/ Works /

L. L. Wei, M. C. Lai, C. W. Ong, Radical Addition to Tricarbonyl[(1-4-h)-2-methoxy-5-methylene-cyclohexa-1,3-diene]iron , Tetrahedron Letts., 2000, 41, 3407.

S. Y. Lee, M. D. Wu, C. W. Wang(Ong), Y. H. Kuo, R. L. Huang, K. H. Lee, A Novel Anti-HbeAg Homolignan, Taiwanschirin D from Kadsura matsudai, Chem. Pharm. Bull. 2000, 48, 1992.

P. C. Shieh; C. W. Ong; Metal carbenoid mediated ring opening of furan-2-yloxy derivatives. Stereoselective synthesis of 2,4-hexadienedioic acid and 6-aryl-1-oxo-2,4-hexadienoic acid derivatives, Tetrahedron, 2001, 57, 7303.

C. W. Ong; M. C Lai. Y. A Chang. Pyrrolizine and Indolizine Derivatives from 1,6-Dioxo-2,4-diene by Inter- and Intramolecular Ring Closure, Heterocycles, 2002, 57, 1303.

C. W. Ong; M.. C Lai. Triene-Tricarbonyl Complexes in Organic Synthesis Trends in Organometallics Chemistry, 2002, vol. 4, 47-58.

A. P. Deng, H. T. Liu, S. J. Jiang, H. J. Huang, C. W. Ong. Reaction Cell Inductively Coupled Plasma Mass Spectrometry-based Immunoassay Using Ferrocene Tethered Hydroxysuccimide Ester as Label for the Determination of 2,4-Dichlorophenoxyacetic Acid, Anal. Chim. Acta, 2002, 472, 55-61.

C. W. Ong, J-L. Han, Some Aspects of Anticancer Drug Activation, Chin. Pharm. J. (review) 2002, 54, 313-329.

C. W. Ong, S-C. Liao, T-H. Chang, H-F. Hsu. Rapid synthesis of new discotic liquid crystals based on diquinoxalino[2,3-a:2’3’-c]phenazine containing hexakis(alkoxy) side arms. Tetrahedron Letts, 2003, 44, 1477-1480.

Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea Y-H. Kuo, A-S. Yu, M-D. Wu, C. W Ong, L-M. Y. Kuo, J-T. Huang, C-F. Chen, S-Y. Li Chem. Pharm. Bull. 2003, 51, 425-426.

C. W. Ong, Y-A Chang. Novel Design of Pentacyclic Scaffold that simulate Saframycin Binding Domains. Tetrahedron, 2003, 59

C. W. Ong; C. Y. Yu; Electronic Control of Product Formation: Rearrangement of 1,3-Dithian-2-yl-arylmethanols. Tetrahedron, 2003, 59, 9677-9682.

M. D. Wu, R-L Huang, L-M Yang Kuo, C-C. Hung, C. W. Ong, Y-H. Kuo. The Anti-HbsAg (Human Type B Hepatitis, Surface Antigen) and Anti HbeAg (Human B Hepatitis, e Antigen) C18 arisanensis. Chem. Pharm. Bull. 2003, 51, 1233-1236.

C. W. Ong, S-C. Liao, T-H Chang, H-F. Hsu, In Situ Synthesis and Mesogenic Properties of the Electron Deficient Discotic Hexakis(alkoxy)hexaazatrinaphthylene Compounds, J. Org. Chem. 2004, 69, 3181-3186.

L. Han, C. W. Ong, Reaction of Tricarbonyl[(1-4-h)-2-methoxy-5-vinylidene-cyclohexa- 1,3-diene]iron Derivatives with Carbene: (2 + 1) Cycloaddition for the Rapid Synthesis of Spiro[2,5]octane, Tetrahedron , 2005, 61,1501-1507.

Y-H. Kuo, M. D. Wu, C-C. Hung, R-L Huang, L-M Yang Kuo, Y. C. Shen, C. W. Ong, Synthesis pf C18 Dibenzocyclooctadiene Lignan Derivatives as Anti-HBsAg and Anti HBeAg Agents, Bioorg. Med. Chem. 2005, 13, 1555-1561.

S-S. Juang, Michael Chang, L. F. Wang, M. C. Lai, C. W. Ong, One Pot Synthesis of Fused [1,2-a]Pyrrole from 1,6-Dioxo-2,4-diene and Haloalkyl Primary Amine, Tetrahedron, 2005, 61, 1693-1697.

H.-F. Hsu, S.-J..Chien, S.-H. Chen, C.-H. Chen, L.-Y. Huang, C.-H. Kou, K.-J. Chen, C. W. Ong, K.-T. Wong “Mesogenic and optical properties of a,a’-bis(4-alkoxy-phenylethynyl) oligothiophenes,” Liq. Cryst., 2005, 32, 683-689.

Y-H. Kuo, M. D. Wu , R-L Huang, L-M Yang Kuo, Y-W Hsu, C-C. Liaw, C-C. Hung, Y. C. Shen, C. W. Ong, Antihepatitis Activity (Anti-HBsAg and Anti HBeAg ) of C19 Homolignans and Six Novel C18 Dibenzocyclooctadiene Lignans from Kadsura japonica. Planta Medica, 2005, 71, 646-653.

T-H. Chang, P-J Wu, Michael Y. Chiang, S-C.Liao, C. W. Ong*, Hsiu-Fu Hsu,‡ and Shu-Yu Lin‡ Synthesis and Mesomorphic Behavior of a Donor-Acceptor-Type Hexaazatriphenylene Organic Letters, 2005, 7, 4075-4078.

/ Patents /

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