/ Members /

Po-Chiao Lin

/ Education /

Associate Professor, Department of Chemistry, National Sun Yat-sen University
Visiting Scholar, Department of Chemical and Biological Engineering, University of Colorado Boulder, USA
Assistant Professor, Department of Chemistry, National Sun Yat-sen University
Research Assistant, Institute of Chemistry, Academia Sinica, Taiwan (National Defense Service)

/ Experience /

Outstanding Teaching Awards, National Sun Yat-sen University (2019)
College of Science Outstanding Teaching Awards, National Sun Yat-sen University (2019)
Outstanding Young Chemist Awards, Chinese Chemical Society (2019)
Asia Core Program Lectureship Awards (Hong Kong) (2019)
Asia Core Program Lectureship Awards (China) (2018)
College of Science Outstanding Teaching Awards, National Sun Yat-sen University (2015)
Royal Society of Chemistry Emerging Investigator Award in Analytical Methods (2015)
Asia Core Program Organic Chemistry Lectureship Awards (2014)
Asia Core Program Lectureship Awards (Korea) (2014)
Asia Core Program Lectureship Awards (Singapore) (2014)
Distinguished Young Scholar, National Sun Yat-sen University (2014)
Max Planck Research Awards, Max Planck Institute, Germany (2009)
Outstanding Paper Awards, Chinese Chemical Society (2008)
Taiwan International Graduate Program (TIGP) Conference Grant (2008)
Paper Awards, Chinese Chemical Society (2003)

/ Works /

1. C.- H. Chou, C.- Y. Wu, C.- L. Chen, J.- Q Zhou, Y.- C. Kao, H.-Y. Chen, P.- C. Lin* “In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence” Chem. Comm. 2020, Advance Article, DOI : 10.1039/ d0cc03090b html
2. J.-G. You, D.-Y. Jin, W.-B. Tseng, W.-L. T*, P.-C. Lin* “Gold(I)‐Thiolate Oligomers for Catalytic Hydrogenation of Nitroaromatics in Aqueous and Organic Medium” ChemCatChem. 2020, 12, 4558-4567 html
3. H.-C. Tu, Y.-P. Lee, X.-Y. Liu, C.-F. Chang, and P.-C. Lin* “Direct Screening of Glycan Patterns from Human Sera: A Selective Glycoprotein Microarray Strategy” ACS Appl. Bio Mater. 2019, 2, 1286.
4. Y.-W. Luo, C.-H. Chou, P.-C. Lin,* and C.-M. Chiang* ” Photochemical Synthesis of Azoarenes from Aryl Azides on Cu(100): A Mechanism Unraveled” J. Phy. Chem. C 2019, 123, 12195.
5. S.-C. Tang, H. Ma, H.-C. Tu, H.-R. Wang, P. C. Lin* and Kristi S. Anseth* “Adaptable Fast Relaxing Boronate – Based Hydrogels for Probing Cell Matrix Interactions” Adv. Science 2018, 1800638. html (SCI impact factor:12.441; 5-Year IF:12.551, ranking: 13/171 (Q1) in chemistry, multidisciplinary)
6. K.-K. Yu, W.-B. Tseng, M.-J. Wu, A. S. K. K. Alagarsamy, W.-L. Tseng*, P.-C. Lin* “Polyadenosine- based fluorescent probe for reversible pH sensing based on protonated adenine-adenine base pairs: Applications to sensing of enzymesubstrate system and enzymatic logic gates” Sens. actuators. B Chem. 2018, 273, 681–688. html (SCI impact factor:5.667; 5-Year IF:5.118, ranking: 2/61 (Q1) in instrument & instrumentation)
7. C.-H. Chou, P.-C. Lin* “Glycan-Directed Grafting-from Polymerization of Immunoglobulin G: Site-Selectively Modified IgG-Polymer Conjugates with Preserved Biological Activity” Biomacromolecules, 2018, 19, 3086–3095. html (SCI impact factor:5.738; 5-Year IF:5.941, ranking: 6/87 (Q1) in polymer science)
8. C.-H. Chou, B. Rajagopal, C.-F. Liang, K.-L. Chen, D.-Y. Jin, H.-Y. Chen*, H.-C. Tu, Y.-Y. Shen, P.-C. Lin* “Synthesis and Photophysical Characterization of 2,3-Dihydroquinolin-4-imines: New Fluorophores with Color-Tailored Emission.” Chem. Eur. J., 2018, 24, 1112–1120.html (SCI impact factor:5.160; 5-Year IF:4.950, ranking: 37/171 (Q1) in Chemistry, multidisciplinary)
9. C.‐C. Chen, S.‐F. Wang, Y.‐Y. Su, Y. A. Lin, P.‐C. Lin* “Copper(I)‐Mediated Denitrogenative Macrocyclization for the Synthesis of Cyclic α3β‐Tetrapeptide Analogues” Chem. Asian J., 2017, 12, 1326–1337 html (SCI impact factor:3.692; 5-Year IF:3.497, ranking: 51/171 (Q1) in Chemistry, multidisciplinary)
10. C.-H. Chou, Y.-Y. Chen, B. Rajagopal, H.-C. Tu, K.-L. Chen, S.-F. Wang, C.-F. Liang, Y.-C. Tyan, and P.-C. Lin* “Thermally Induced Denitrogenative Annulation for the Synthesis of Dihydroquinolinimines and Chroman-4-imines” Chem. Asian J., 2016, 11, 757–765.html (SCI impact factor:3.692; 5-Year IF:3.497, ranking : 51/171 (Q1) in Chemistry, multidisciplinary)
11. Y.-Y. Chen, K.-L. Chen, Y.-C. Tyan, C.-F. Liang, P.-C. Lin* “Synthesis of substituted 3-methylene-2,3-dihydrobenzofurans and 3-methylbenzofurans by rhodium (II)-catalyzed annulation” Tetrahedron, 2015, 71, 6210-6218. html (SCI impact factor:2.377; 5-Year IF:2.255, ranking : 23/57 (Q2) in Chemistry, organic)
12. C.-C. Chen, P.-C. Lin* “Monitoring of chemical transformations by mass spectrometry.” Anal. Methods, 2015, 7, 6947–6959. html (SCI impact factor:2.073; 5-Year IF:2.000 , ranking: 52/133 (Q2) in food science & technology)
13. B. Rajagopal, C.-H. Chou, C.-C. Chung, P.-C. Lin* “Synthesis of Substituted 3-Indolylimines and Indole-3-carboxaldehydes by Rhodium (II)-Catalyzed Annulation.” Org. Lett. 2014, 16, 3752–3755. html (SCI impact factor:6.492; 5-Year IF:5.778, ranking: 3/57 (Q1) in chemistry, organic)
14. B. Rajagopal, Y.-Y. Chen, C.-C. Chen, X.-Y. Liu, H.-R. Wang, P.-C. Lin* “Cu(I)-Catalyzed Synthesis of Dihydropyrimidin-4-ones toward the Preparation of β- and β3-Amino Acid Analogues” J. Org. Chem. 2014, 79, 1254–1264. html (SCI impact factor:4.805; 5-Year IF:4.313, ranking: 9/57 (Q1) in chemistry, organic)
15. Y.-L. Yang, Y.-P. L., Y.-L. Yang, P.-C. Lin* “Traceless Labeling of Glycoproteins and Its Application to the Study of Glycoprotein-protein Interact” ACS Chem. Biol. 2014, 9, 390-397. html (SCI impact factor:4.592; 5-Year IF:4.794, ranking: 57/292 (Q1) in biochemistry & molecular biology)
16. C.-C. Chen, B. Rajagopal, X.-Y. Liu, K.-L. Chen, Y.-C. Tyan, F. Lin, P.-C. Lin* “A mild removal of Fmoc group using sodium azide” Amino Acids, 2014, 46, 367–374.html ; 5-Year 2.906SCI impact factor:(:2.946, ranking:148/292 (Q3) in biochemistry & molecular biology)IF
17. S. Hsieh*, S.-L. Hsieh, C.-W. Hsieh, P.-C. Lin, C.-H. Wu “Label-free glucose detection using cantilever sensor technology based on gravimetric detection principles” J. Anal. Methods. Chem. 2013, Article ID 687265.html (SCI impact factor:1.262; 5-Year IF:1.722, ranking:75/128 (Q3) in engineering, civil)
18. Y.-W. Lu, C.-W. Chien, P.-C. Lin, L.-D. Huang, C.-Y. Chen, S.-W. Wu, C.-L. Han, K.-H. Khoo, C.-C Lin.*, Y.-J. Chen* “BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichmentof Glycoproteins” Anal. Chem. 2013, 85, 8268-8276. html (SCI impact factor:6.042; 5-Year IF:6.035, ranking:4/80 (Q1) in chemistry, analytical)
19. C.-C. Chen, Y.-L. Yang, C.-L. Ou, C.-H. Chou, C.-C. Liaw, P.-C. Lin* “Direct Monitoring of Chemical Transformations by Combining Thin Layer Chromatography with Nanoparticle-assisted Laser Desorption /Ionization Mass Spectrometry” Analyst, 2013, 138, 1379–1385. html SCI impact factor:3.864; 5-Year IF:3.791, ranking:11/80 (Q1) in chemistry, analytical)
20. Y.-L. Yang, B. Rajagopal, C.-F. Liang, C.-C. Chen, H.-P. Lai, C.-H. Chou, Y.-P. Lee, Y.-L. Yang, J.-W. Zeng, C.-L. Ou, P.-C. Lin* “Chemoselective Synthesis of Aryl Carboxamido Sulfonic Acid Derivatives” Tetrahedron, 2013, 69, 2640–2646.html (SCI impact factor:2.377; 5-Year IF:2.255, ranking: 23/57 (Q2) in chemistry, organic)
21. P.-C. Lin*, C.-C. Yu, H.-T. Wu, Y.-W. Lu, C.-L. Han, A.-K. Su, Y.-J. Chen*, C.-C. Lin* “A Chemically Functionalized Magnetic Nanoplatform for Rapid and Specific Biomolecular Recognition and Separation” Biomacromolecules, 2013, 14, 160-168. html (SCI impact factor:5.738; 5-Year IF:5.941, ranking: 6/87 (Q1) in polymer science)
22. L. Yi, Y.-X. Chen, P.-C. Lin, Schröder H, C.-M. Niemeyer, Y.-W. Wu, R.-S. Goody, G. Triola*, H. Waldmann* “Direct immobilization of oxyamine-modified proteins from cell lysates.” Chem. Commun. 2012, 48, 10829-10831. html
23. R.-P. Obena, P.-C. Lin, Y.-W. Lu, I.-C. Li, F. Del Mundo, S. D. Arco, G.M. Nuesca, C.-C. Lin*, Y.-J. Chen, “Iron oxide nanomatrix facilitating metal ionization in matrix-assisted laser desorption/ionization mass spectrometry.” Anal. Chem. 2011, 83, 9337–9343. html
24. H.-T. Wu, C.-C. Hsu, C.-F. Tsai, P.-C. Lin, C.-C. Lin* and Y.-J. Chen,” Nanoprobe based Immobilized Metal Affinity Chromatography for Enhanced Enrichment of Multiply Phosphorylated Peptides” Proteomics, 2011, 11, 2639–2653. html
25. W.-C. Chen, P.-C. Lin, C.-H. Chen, C.-T. Chen “Modulation of Photoswitching Profiles by 10,11-Dialkoxymethyl Substituents in C2-Symmetric Dibenzosuberane-Based Helicenes” Chem. Eur. J., 2010, 43, 12822–12830. html
26. M.-C. Tseng, R. Obena, Y.-W. Lu, P.-C. Lin, P.-Y. Lin, Y.-S. Yen, J.-T. Lin, L.-D. Huang, K.-L. Lu, L.-L. Lai, C.-C. Lin, Y.-J. Chen “Dihydrobenzoic Acid Modified Nanoparticle as a MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures” J. Am. Soc. Mass Spectrom, 2010, 11, 1930–1939.html
27. D. Weinrich, P.-C. Lin, P. Jonkheijm, H. Schröder, C. M. Niemeyer, K. Alexandrov, H. Waldmann. “Oriented Immobilization of Farnesylated Proteins by Thiol-Ene Reaction” Angew. Chem. Int. Ed. 2010, 49,1252–1257. html
28. P.-C. Lin, D. Weinrich, H. Waldmann “Protein Biochips: Oriented Surface Immobilization of Proteins” Marcromol. Chem. Phys. 2010, 211, 136–144. hmtl
29. P.-C. Lin, A. K. Adak, S.-H. Ueng, L.-D. Huang, K.-T. Huang, C.-C. Lin*, “ DAST-Mediated Regioselective Anomeric Group Migration in Saccharides” J. Org. Chem. 2009, 74, 4041–4048.hmtl
30. P.-C. Lin, S.-H. Chen, M.-L. Chen, A. Kumar Adak, Y.-J. Chen* and C.-C. Lin*, “Fabrication of Oriented Antibody-Conjugated Magnetic Nanoprobes and Their Immunoaffinity Application” Anal. Chem. 2009, 81, 8774–8782 html
31. P.-C. Lin, H.-T. Wu, K.-Y. Wang, Y.-J. Chen, C.-C. Lin, “Development and Application of Functionalized Nanoparticles on Mass Spectrometry for the Analysis of Target Biomolecules” Instruments Today, 2008, 29, 68. (in Taiwan) html
32. K.-Y. Wang, S.-A. Chuang, P.-C. Lin, S.-H. Chen, L.-S. Huang, C.-C. Lin, and Y.-J. Chen* “Multiplexed Immunoassay: Quantitation and Profiling of Serum Biomarkers Using Magnetic Nanoprobes and MALDI-TOF MS” Anal. Chem. 2008, 80, 6159–6167. html
33. P.-H. Shih, J.-Y. Shiu, P.-C. Lin, C.-C. Lin, T. Veres, P. Chen “On chip sorting of bacterial cells using sugar-encapsulated magnetic nanoparticles” J. Appl. Phys. 2008, 103, 07A316. html
34. C.-C. Yu, P.-C. Lin, C.-C. Lin* “Site-specific CMP-sialic acid synthetase Immobilized Magnetic Nanoparticle in the synthesis of CMP-sialic acid” Chem. Commun. 2008, 0, 1308–1310. html
35. T.-C. Chiu, L.-S. Huang, P.-C. Lin, Y.-C. Chen, Y.-J. Chen, C.-C. Lin, H.-T. Chang, “Nanomaterial Based Affinity Matrix-assisted Laser Desorption/Ionization Mass Spectrometry for Biomolecules and Pathogenic Bacteria” Recent patents on Nanotechnology, 2007, 1, 99–111. html
36. P.-C. Lin, S.-H. Ueng, S.-C. Yu, M.-D. Jan, A. K. Adak, C.-C. Yu, C.-C. Lin* “Surface Modification of Magnetic Nanoparticle via Cu(I)-Catalyzed Alkyne-azide [2 + 3] Cycloaddition” Org. Lett. 2007, 9, 2131–2134. html
37. P.-C. Lin, M.-C. Tseng, A.-K. Su, Y.-J. Chen*, C.-C. Lin* “Functionalized Magnetic Nanoparticles for Small-Molecule Isolation, Identification, and Quantification” Anal. Chem. 2007, 79, 3401–3408. html
38. P.-C. Lin, S.-H. Ueng, M.-C. Tseng, J.-L. Ko, K.-T. Huang, S.-C. Yu, A. K. Adak, Y.-J. Chen, C.-C. Lin,* “Site-Specific Protein Modification through CuI-Catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication“ Angew. Chem. Int. Ed. 2006, 45, 4286–4290. html
39. P.-C. Lin, P.-H. Chou, S.-H. Chen, H.-K. Liao, K.-Y. Wang, Y.-J. Chen, C.-C. Lin* “Ethylene Glycol-Protected Magnetic Nanoparticles for a Multiplexed Immunoassay in Human Plasma” Small, 2006, 2,485–489. html
40. P.-H. Chou, S.-H. Chen, H.-K. Liao, P.-C. Lin, G.-R. Her, Alan C.-Y. Lai, J.-H. Chen, C.-C. Lin*, Y.-J. Chen* “Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma” Anal. Chem. 2005, 77, 5990–5997. html
41. Po-chiao Lin, Yung-lin Yang, Yen-pin Lee (2016): Method of traceless labeling glycoproteins on surface and application thereof, U. S. Appl. Publ. US20160123988A1
42. Po-Chiao Lin, Chun-Chi Chen (2013): Method for detecting by thin-layer chromatograph mass spectrometry, Taiwan (R.O.C.) Appl. Publ. TW201443432A
43. Y.-J. Chen, P.-C. Lin, C.-C. Lin, S.-H. Chen, P.-H. Chou, H.-K. Liao (2007): Mass spectrometric analysis of ligand conjugated magnetic nanoparticles, U. S. Appl. Publ. US20070054407
44. L.-S. Huang, Y.-Y. Chien, S.-H. Chen, P.-C. Lin, K.-Y. Wang, P.-H. Chou, C.-C. Lin, and Y.-J.Chen,“Nanoprobe-based Affinity Mass Spectrometry for Cancer Marker Protein Profiling”inNanomaterials for Cancer Diagnosis; Eds: Challa S. S. R. Wiley-VCH, 2007
45. P.-C. Lin, A. Kumar Adak, and C.-C. Lin*,“Fabrication and applications of glyconanomaterials.” inThe Molecular Immunology of Complex Carbohydrates-3; Eds: Albert M. Wu, Kluwer Academia/Plenum Publishers, 2011
46. Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chien-Hui Lai, Po-Chiao Lin,* Chun-Cheng Lin,*Functionalized glyconanoparticles for the study of glycobiology” in Glyco-nanotechnology as a bridge tonew medicines, ACS Symposium Series 1091, 2011, chapter 2, p15-36.

/ Patents /