Ming-Jung Wu

Office: C6001

Lab: C6004

Tel: 886-7-525-2000 ext 3914

Fax: 886-7525-3909

E-mail: mijuwu@faculty.nsysu.edu.tw


EDUCATIONS:

BS in Chemistry, National Tsing Hua University, Hsin Chu, Taiwan (1979)

PhD in Chemistry, Clemson Unversity, SC, USA (1987)

EXPERIENCES:

1.      Professor, Department of Chemistry, National Sun Yat-sen University (2008-present).

2.      Professor, Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University (1994 -2008).

3.      Associate Professor, School of Chemistry, Kaohsiung Medical College (1990 - 1994).

4.      Research Fellow, Synthetic Department, Smith Kline & Beechem Pharmaceuticals (1989 - 1990).

5.      Postdoctoral Fellow, Department of Chemistry, The Pennsylvania State University (1987 - 1989).

6.      Director, Life-span and career planning center, Kaohsiung Medical University (1994-2000).

7.      Dean of Student Affairs, Kaohsiung Medical University (2000 -2006).

AWARDS & HONORS:

1.      Research Achievement Award, Natinal Science Council (1991-2000).

2.      Outstanding Teaching Awards, Kaohsiung Medical University (1997, 2002, 2004).

3.      Outstanding Research Awards, Kaohsiung Medical University (2001, 2002, 2004)

4.      Outstanding Research Award, Kaohsiung Medical University Alumni Foundation (2004).

5.      Asian Core Program Lectureship Award, Japan (2008)

6.      Asian Core Program Lectureship Award, Singapore (2010)

7.      Asian Core Program Lectureship Award, Korea (2012)

8.      Asian Core Program Lectureship Award, China (2014)


RESEARCH INTERESTS:
1. Transition metal catalyzed organic reactions.
2. Design and synthesis of new antitumor agents.
3. Total synthesis of natural products.

SELECTED PUBLICATIONS:

  1. Chih-Jyun-Tsai,Chin-Chau-Chen,Chih-Wei,Tsai,Ming-Jung Wu* Base-Mediated Cyclization Reaction of 2-(5-Hydroxy-1-pentynyl)benzonitriles To 4-Amino-2,3-dihydronaphtho[2,3-b]furanes and Synthesis of Furanonaphthoquinones
    “J. Org. Chem 2016,81卷,9期,3882-3889”

  2. Hung-Chou Wu,Jean-Ho Chu*,Chin-Wei Li,Long-Chih Hwang, Ming-Jung Wu* Palladium-Catalyzed Regioselective Arylation of Pyrazolo[1,5-α]pyridines via C-H Activation and Synthetic Applications on P38 Kinase Inhibitors
    “Organometallics 2016,35卷02期,288-300”

  3. CLi-Lan Wei,Li-Mei Wei,Po-Yang Lin,Chin-Chau Chen, Wen-Bin Pan*,Ming-Jung Wu* Palladium(0)-catalyzed 5-exo-dig O-cyclization/coupling of ethyl 3-(2-alkynylphenyl)-3-oxopropanoates with aryl iodides to 1,3-dihydroisobenzofurans
    “Tetrahedron Lett 2015,56卷,47期,6629-6632”

  4. Jean-ho Chu,Shih-Tien Chen,Meng-Fan Chiang,and Ming-Jung Wu* Palladium-Catalyzed Direct Ortho Aroylation of 2-Phenoxypyridines with Aldehydes and Catalytic Mechanism Investigation
    “Organometallics 2015,34卷05期,953-966”

  5. Chin-Chau Chen,Chu-Mei Chen, and Ming-Jung Wu* Transition Metal-Catalyzed Cascade Cyclization of Aryldiynes to Halogented Benzo[b]naphtho[2,1-d]thiophene Derivatives
    “J. Org. Chem 2014,79卷10期,4704-4711”

  6. Jean-Ho Chu,Hao-Ping Huang,Wen-Ting Hsu,Shih-Tien Chen and Ming-Jung Wu* Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via C-H Activation/C-C Coupling and Synthetic Applications
    “Organometallics 2014,33卷05期,1190-1204”

  7. Jean-Ho Chu*, Wen-Ting Hsu, Yi-Hua Wu, Meng-Fan Chiang, Nan-Hai Hsu, Hao-Ping Huang, and Ming-Jung Wu* Substituent Electronic Effects Direct Intramolecular C-N Cyclization of N-(Biphenyl)pyridine-2-amines Induced by Hypervalent Iodine(III) Reagents
    “J. Org. Chem 2014,79卷23期,11395-11408”

  8. Chuang DW, Mohamed ES, Chen CC, Chung YM, Brave BD, Wu MJ, Chang FR, Wu YC* Synthesis of 1,5-diphenylpent-3-en-1-yne derivatives utilizing an aqueous B-alkyl Suzuki cross coupling reaction.
    “Tetrahedron Lett 2013,54卷,38期,5162-5166”

  9. Cheng-Han Lin, Chin-Chau Chen, and Ming-Jung Wu* Mercury(II)-Catalyzed Cyclization of 2-Alkynylphenyl Alkyl Sulfoxides Provides 3-Acylbenzo[b]thiophenes
    .”Chem.Eur. J. 2013,19卷08期,2578-2581”

  10. Yu-Hsiang Lo , Ying-Ting Lin , Yu-Peng Liu , Tsai-Hui Duh , Pei-Jung Lu, Ming-Jung Wu* Design, synthesis, biological evaluation and molecular modeling studies of 1-aryl-6-(3,4,5-trimethoxyphenyl)-3(Z)- hexen-1,5-diynes as a new class of potent antitumor agents
    “Eur. J Med Chem 2013,62卷,526-533”

  11. Jean-Ho Chu, Chung-Chiu Wu, Deng-Hsiang Chang, Ya-Ming Lee, and Ming-Jung Wu* Direct Ortho Arylation of 9 (Pyridin-2-yl)9H carbazoles Bearing a Removable Directing Group via Palladium(II)-Catalyzed C?H Bond Activation
    “Organometallics 2013,32卷01期,272-282”

  12. Wen-Bin Pan, Chin-Chau Chen, Li-Lan Wei, Li-Mei Wei, Ming-Jung Wu* One-pot synthesis of 2,20-bisbenzofurans using cuprous chloride as a catalyst
    “Tetrahedron Lett 2013,54卷21期,2655-2657”

  13. Hung-Chou Wu, Chia-Wen Yang, Long-Chih Hwang and Ming-Jung Wu* Au(I)-catalyzed and iodine-mediated cyclization of enynylpyrazoles to provide pyrazolo[1,5-a]pyridines
    “Org. Biomol. Chem. 2012,10卷33期,6640-6648”

  14. Jean-Ho Chu,Pi-Shan Lin,Ya-Ming Lee,Wei-Ting Shen,Ming-Jung Wu* ”Palladium(II)-Catalyzed One-Pot Syntheses of 9-(Pyridin-2-yl)-9H-carbazoles through a Tandem C-H Activation/C-X(X=C or N)Formation Process”.
    “Chem. Eur. J 2011,17卷48期,13613-13620”

  15. Chin-Chau Chen, Shyh-Chyun Yang, Ming-Jung Wu* ”Iodine-Mediated Cascade Cyclization of Enediynes to Iodinated Benzo[a]carbazoles”.
    “J. Org. Chem 2011,76卷24期,10269-10274”

  16. H. C. Wu, L. C. Hwang, M. J. Wu,* “Copper-Mediated Cyclization Reaction of Enediynones with Hydrazine Provides Pyrazolo[1,5-a]pyridines”
    “Org. Biomol. Chem. 2011, 9卷03期, 670-672”

  17. C. C. Chen, L. Y. Chin, S. C. Yang, M. J. Wu,* “Synthetic Development and Mechanistic Study on Pd(II)-Catalyzed Cyclization of Enediynes to Benzo[a]carbazoles”
    “Org. Lett. 2010, 12卷24期, 5652.-5655”

  18. J. H. Chu, P. S. Lin, M. J. Wu,* “Palladium(II)-Catalyzed Ortho Arylation of 2-Phenoxypyridines with Potassium Aryltrifluoroborates via C-H Functionalization”
    “Organometallics 2010, 29卷18期, 4058-4065”

  19. C. W. Tsai, S. C. Yang, Y. M. Liu, M. J. Wu* “Microwave-assisted Cycloaddition of 2-Alkynylbenzonitriles with Sodium Azides: Selective Synthesis of Tetrazolo[5,1-a]pyridines and 4,5-Disubstituted-2H-1,2,3-triazoles”
    “Tetrahedron 2009, 65, 8367-8372”

  20. J. H. Chu, S. L. Tsai, M. J. Wu* “Palladium(II)-Catalyzed ortho Arylation of 2-Phenylpyridines with Potasium Aryltrifluoroborates by C-H Functionalization”
    “Synthesis 2009, 3757-3764.”

  21. J. H. Chu, Y. J. Chen, M. J. Wu* “Mild Oxidation of Diarylacetylenes to 1,2-Diketones Using Oxone in Trifluoroacetic acid”
    “Synthesis, 2009, 2155-2162.”

  22. C. Y. Kuo,* M. J. Wu “The Synthesis of N-Phenoxyethyl-1-substituted-1,2,3,4-tetrahydroisoquinolines and Their 1-adrenoceptor Blocking Activity”
    “Eur. J. Med. Chem. 2009, 44, 1271-1277”

  23. K. F. Tseng, C. F. Lin, Y. H. Lo, Y. L. Hu, L. Y. Chen, S. H. Yang, S. R. Lin, L. S. Chang, M. J. Wu* “Synthesis and Biological Evalution of Novel Symmetry Bis-enediynes”
    “Eur. J. Med. Chem. 2009, 44, 35-41.”

  24. Y. S. Tu, T. H. Duh, C. Y. Tseng, Y. T. Lin, Y. H. Lo, Y. L. Hu, C. H. Chen, C. M. Chien, S. H. Yang, Lin, S. R. S. C. Yang, M. J. Wu* “1-(2-((Z)-6-(2-Trifluoromethylphenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one as a New Potent Apoptosis Agent”
    “Bioorg. Med. Chem. 2009, 17, 7412-7417.”

  25. W. P. Hu, J. J. Liang, C. L. Kao, Y. C. Chen, C. Y. Chen, F. Y. Tsai, M. J. Wu, L. S. Chang, Y. L. Chen, J. J. Wang* “Synthesis and Antitumor Activity of Novel Enediyne-linked Pyrrolo[2,1-c][1,4]benzodiazepine hybrids”
    “Bioorg. Med. Chem. 2009, 17, 1172-1180.”