蔣燕南副教授

◆研究室:C5013

◆實驗室:C5012

◆電話:(07)5252000 轉 3949

◆e-mail:michael@mail.nsysu.edu.tw


學經歷

◇副教授(1992)
◇美國密蘇里州華盛頓大學X光研究室主任(1988)
◇美國紐約哥倫比亞大學X光實驗室主任 (1984)
◇美國南加州大學化學博士(1984)
◇輔仁大學理學士(1976)


研究興趣

本研究室之研究領域為生物無機化學及有機金屬化學。研究技巧涉及真空系統操作下的合成技術及一般光譜鑑定並偏重 X-光單晶繞射結構解析。 X-光單晶繞射結構解析。
主要研究方向分為三類︰

(1)化學結晶學— 晶體結構解析及晶體資料庫分析
超分子結構解析,單晶或粉末樣品檢測,絕對構型鑑定等。

(2) 有機金屬化學— 高分子合成催化劑
以含氮硫之雙牙或多牙配子與金屬(鋁鈦銅鋅)離子結合的催化劑,研究易生化降解高分子的催化性能。

(3) 無機生物化學— 酵素模擬
以含氮、磷、或硫之多牙配位基與金屬離子作用來模擬含銅或鋅酵素(如超氧歧化酵素、甲基轉移酵素)活性中心之水解、氧化還原、烷基轉移等反應。


代表著作(均為SCI論文)

  1. Wan-Jung Chuang, Yen-Tzu Huang, Yu-Hsieh Chen, Yu-Shan Lin, Wei-Yi Lu,Yi-Chun Lai, Michael Y. Chiang,* Sodio C. N. Hsu* and Hsuan-Ying Chen*, “Synthesis, characterization, and catalytic activity of sodium ketminiate complexes toward the ringopening polymerization of L-lactide” , RSC Adv., 2016, 6, 33014–33021.

  2. Hsi-Ching Tseng, Hsing-Yin Chen, Yen-Tzu Huang, Wei-Yi Lu, Yu-Lun Chang, Michael Y. Chiang, Yi-Chun Lai, and Hsuan-Ying Chen*, “Improvement in Titanium Complexes Bearing Schiff Base Ligands in the Ring-Opening Polymerization of L Lactide: A Dinuclear System with Hydrazine-Bridging Schiff Base Ligands”, Inorg. Chem. 2016, 55, 1642−1650.

  3. Yen-Tzu Huang, Wei-Chu Wang, Chun-Pin Hsu, Wei-Yi Lu, Wan-Jung Chuang, Michael Y. Chiang, Yi-Chun Lai and Hsuan-Ying Chen* “The ring-opening polymerization of ε-caprolactone and L-lactide using aluminum complexes bearing benzothiazole ligands as catalysts”, Polym. Chem., 2016, 7, 4367–4377.

  4. Wan-Jung Chuang, Hsing-Yin Chen, Wei-Ting Chen, Heng-Yi Chang, Michael Y. Chiang, Hsuan-Ying Chen* and Sodio C. N. Hsu*, “Steric and chelating ring concerns on the L-lactide polymerization by asymmetric b-diketiminato zinc complexes”, RSC Adv., 2016, 6, 36705– 36714.

  5. Yu-Hsieh Chen, Yen-Jen Chen, Hsi-Ching Tseng, Cheng-Jie Lian, Hsin-Yi Tsai, Yi-Chun Lai, Sodio C. N. Hsu, * Michael Y. Chiang* and Hsuan-Ying Chen*, “Comparing L-lactide and -caprolactone polymerization by using aluminum complexes bearing ketiminate ligands: steric, electronic, and chelating effects” RSC Adv., 2015, 5, 100272–100280.

  6. Meng-Chih Chang, Wei-Yi Lu, Heng-Yi Chang, Yi-Chun Lai, Michael Y. Chiang,* Hsing-Yin Chen,* and Hsuan-Ying Chen*, “Comparative Study of Aluminum Complexes Bearing N,O- and N,S-Schiff Base in Ring-Opening Polymerization of ε-Caprolactone and L-Lactide” Inorg. Chem. 2015, 54, 11292−11298.

  7. Hsiu-Wei Ou, Michael Y. Chiang, Jaya Kishore Vandavasi, Wei-Yi Lu, Yen-Jen Chen, Hsi-Ching Tseng, Yi-Chun Lai and Hsuan-Ying Chen*,” Comparative study of ring-opening polymerization of L-lactide and  -caprolactone using zirconium hexadentate bis(aminophenolate) complexes as catalysts” RSC Adv., 2015, 5, 477–484.

  8. Lin, Yen-You; Tsai, Su-June; Chiang, Michael Y., Wen Zhi-Hong; Su, Jui-Hsin, “Anti-inflammatory anthraquinones from the crinoid Himerometra magnipinna”, Natural Product Communications, 2015, 10(2), 317-318.

  9. Liou, Jing-Ru; Wu, Tung-Ying; Thang, Tran Dinh; Hwang, Tsong-Long; Wu, Chin-Chun; Cheng, Yuan-Bin; Chiang, Michael Y.; Lan, Yu-Hsuan; El-Shazly, Mohamed; Wu, Shwu-Li; Beerhues, Ludger; Yuan, Shyng-Shiou; Hou, Ming-Feng; Chen, Shu-Li; Chang, Fang-Rong; Wu, Yang-Chang , “Bioactive 6S-Styryllactone Constituents of Polyalthia parviflora”, J. Nat. Prod., 2015, 77(12), 2626-2632.

  10. Tsung-Chang Tsai, Hsueh-Yu Chen, Jyh-Horng Sheu, Michael Y. Chiang, Zhi-Hong Wen, Chang-Feng Dai, and Jui-Hsin Su, “Structural Elucidation and Structure−Anti- inflammatory Activity Relationships of Cembranoids from Cultured Soft Corals Sinularia sandensis and Sinularia f lexibilis” J. Agric. Food Chem. 2015, 63, 7211−7218.

  11. Bo-Wei Chen, Yang-Yih Chen, You-Cheng Lin, Chiung-Yao Huang, Chokkalingam Uvarani, Tsong-Long Hwang, Michael Y. Chiang, Ho-Yih Liu and Jyh-Horng Sheu,” Capsisteroids A–F, withanolides from the leaves of Solanum capsicoides” RSC Advance, 2015, 5, 88841–88847.

  12. Hsing-Yin Chen, Ying-Hsien Lee, Michael Y. Chiang, Wei-Yi Lu, Hsi-Ching Tseng, Hsin-Yi Tsai, Yu-Hsieh Chen, Yi-Chun Lai and Hsuan-Ying Chen*, “Coordinating effect in ring-opening polymerization of -caprolactone using aluminum complexes bearing bisphenolate as catalysts” RSC Adv., 2015, 5, 82018–82026.

  13. Hsi-Ching Tseng, Fu-Shen Chen, Michael Y. Chiang, Wei-Yi Lu, Yu-Hsieh Chen, Yi-Chun Lai and Hsuan-Ying Chen* “Optimizing ring-opening polymerization of -caprolactone by using aluminum complexes bearing amide as catalysts and their application in synthesizing poly--caprolactone with special initiators and other polycycloesters” RSC Adv., 2015, 5, 90682–90690.

  14. Hsi-Ching Tseng, Michael Y. Chiang, Wei-Yi Lu, Yen-Jen Chen, Cheng-Jie Lian, Yu-Hsieh Chen, Hsin-Yi Tsai, Yi-Chun Lai and Hsuan-Ying Chen*, “A closer look at ε-caprolactone polymerization catalyzed by alkyl aluminum complexes: the effect of induction period on overall catalytic activity” Dalton Trans., 2015, 44, 11763–11773.

  15. Chao-Ying Kuo, Yung-Shun Juan, Mei-Chin Lu, Michael Yen-Nan Chiang, Chang-Feng Dai, Yang-Chang Wu,* and Ping-Jyun Sung*, “Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis”, Int. J. Mol. Sci., 2014, 15, 10136-10149.

  16. Zuo-Fu Wei, Yung-Husan Chen, Ping-Jyun Sung, Guey-Horng Wang, Jing-Ru Liou, Sheng-Yang Wang, Shang-Tzen Chang, Yuan Gang Zu, Michael Y. Chiang, Yu-Jie Fu* and Fang-Rong Chang*, “Equisetumone, a novel 4-5-olide secocaryophyllane sesquiterpene from Equisetum palustre”, RSC Advances, 2014, 4(86), 45749-45752.

  17. Yuan-Bin Cheng, Chih-Chin Lan, Wei-Chun Liu, Wan-Chun Lai, Yu-Chi Tsai, Michael Y. Chiang, Yang-Chang Wu, Fang-Rong Chang*, “Kuroshines A and B, new alkaloids from Zoanthus kuroshio” Tetrahedron Letters, 2014, 55(39), 5369–5372.

  18. Hsun-Shuo Chang, Michael Y. Chiang, Hsing-Yu Hsu, Cheng-Wei Yang, Chu-Hung Lin, Shiow-Ju Lee, Ih-Sheng Chen, “Cytotoxic cardenolide glycosides from the root of Reevesia formosana”, Phytochemistry, 2013, 87, 86–95.

  19. Li-Chung Hu, Jui-Hsin Su, Michael Yen-Nan Chiang, Mei-Chin Lu, Tsong-Long Hwang, Yung-Husan Chen, Wan-Ping Hu, Nai-Cheng Lin, Wei-Hsien Wang, Lee-Shing Fang, Yueh-Hsiung Kuo* and Ping-Jyun Sung*, “Flexibilins A−C, New Cembrane-type Diterpenoids from the Formosan Soft Coral Sinularia flexibilis”, Marine Drugs, 2013, 11, 1999-2012.

  20. Li-Chung Hu, Wei-Hsuan Yen, Jui-Hsin Su, Michael Yen-Nan Chiang, Zhi-Hong Wen, Wu-Fu Chen, Ting-Jang Lu, Yu-Wei Chang, Yung-Husan Chen, Wei-Hsien Wang, Yang-Chang Wu*, and Ping-Jyun Sung*, “Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis”, Marine Drugs, 2013, 11, 2154-2167.

  21. Jui-Hsin Su, Yu-Cheng Chen, Mohamed El-Shazly, Ying-Chi Du, Chiang-Wen Su, Chia-Wei Tsao, Li-Lian Liu, Yalan Chou, Wen-Been Chang, Yin-Di Su, Michael Y. Chiang, Yao-Tsung Yeh and Mei-Chin Lu*, “Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway”, Marine Drugs, 2013, 11, 3168-3185.

  22. Yi-Hsun Chen, Troy T.Y. Lin, Hsuan-Ying Chen, Chai-Lin Kao, Hsing-Yin Chen, Sodio C.N. Hsu*, James R. Carey*, Michael Y. Chiang*, “A simple competition assay to probe pentacopper(I)-thiolato cluster ligand exchange”, J. Inorg. Biochem. 2013, 120, 24–31.

  23. Yu-Chi Lin, Yuan-Bin Cheng, Chia-Ching Liaw, I-Wen Lo, Yao-Haur Kuo, Michael Y. Chiang, Chang-Hung Chou and Ya-Ching Shen*, “New Lignans from the Leaves and Stems of Kadsura philippinensis”, Molecules, 2013, 18,6573-6583.

  24. Chiung-Yao Huang, Chih-Chuang Liaw, Bo-Wei Chen, Pei-Chin Chen, Jui-Hsin Su, Ping-Jyun Sung, Chang-Feng Dai, Michael Y. Chiang, and Jyh-Horng Sheu*, “Withanolide-Based Steroids from the Cultured Soft Coral Sinularia brassica”, J. Nat. Prod. 2013, 76, 1902−1908.

  25. Tzu-Rong Su, Kai-Ju Liang, Michael Y. Chiang, Mei-Chin Lu, Yu-Jen Wu* and Jui-Hsin Su*, “5α,8α-Epidioxysterols from a Formosan Sponge, Axinyssa sp.”, Nat. Prod. Comm. 2013, 8(11), 1535-1536.

  26. Po-Yuan Chen, Hsing-Ming Chen, Michael Y. Chiang, You-Feng Wang, Sie-Rong Li, Tzu-Pin Wang, Eng-Chi Wang,* “A novel and chemoselective synthesis of substituted 3,4-dihydroisoquinolin-1(2H)-ones from o-oxiranylmethylbenzonitrile intermediates and TBAB/NaCN” Tetrahedron, 2012, 68, 3030-3036.

  27. Yu-Chieh Chien, Chu-Hung Lin, Michael Y. Chiang, Hsun-Shuo Chang, Chang-Hui Liao, Ih-Sheng Chen, Chien-Fang Peng, Ian-Lih Tsai*, “Secondary metabolites from the root of Ehretia longiflora and their biological activities” Phytochemistry, 2012, 80, 50-57.

  28. Sodio C. N. Hsu*, Yu-Lun Chang, Wan-Jung Chuang, Hsing-Yin Chen*, I-Jung Lin, Michael Y. Chiang, Chai-Lin Kao, and Hsuan-Ying Chen, “Copper(I) Nitro Complex with an Anionic [HB(3,5-Me2Pz)3]− Ligand: A Synthetic Model for the Copper Nitrite Reductase Active Site” Inorg. Chem. 2012, 51, 9297−9308.

  29. Po-Yuan Chen, Tzu-Pin Wang, Michael Y. Chiang, Keng-Shian Huang, Cherng-Chyi Tzeng,Yi-Long Chen, Eng-Chi Wang “Environmentally benign syntheses of flavanones” Tetrahedron, 2011, (67), 4155-4160.

  30. Attila Hunyadi, Da-Wei Chuang, Balazs Danko, Michael Y. Chiang, Chia-Lin Lee, Hui-Chun Wang, Chin-Chung Wu, Fang-Rong Chang*, Yang-Chang Wu “Direct Semi-Synthesis of the Anticancer Lead-Drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives” PLoS ONE, 2011, 6(8), e23922

  31. Pei-Chin Lin, Hsing-Yin Chen, Po-Yu Chen, Ming-Hsi Chiang, Michael Y. Chiang, Ting-Shen Kuo, and Sodio C. N. Hsu* “Self-Assembly and Redox Modulation of the Cavity Size of an Unusual Rectangular Iron Thiolate Aryldiisocyanide Metallocyclophane” Inorg. Chem. 2011, 50, 10825−10834.

  32. Jui-Hsin Su, Yi Lu, Wen-Yu Hung, Chiung-Yao Huang, Michael Y. Chiang, Ping-Jyun Sung, Yao-Haur Kuo, and Jyh-Horng Sheu*, “Sesquiterpenoids from the Formosan Soft Coral Lemnalia flava” Chem. Pharm. Bull. 2011, 59(6), 698-702.

  33. Bi-Jiuan Liou, Hsun-Shuo Chang, Guei-Jane Wang, Michael Y. Chiang, Chang-Hui Liao, Chu-Hung Lin, Ih-Sheng Chen “Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them” Phytochemistry, 2011, 72, 415-422.

  34. Yi Lu, Po-Ju Li, Wen-Yu Hung, Jui-Hsin Su, Zhi-Hong Wen, Chi-Hsin Hsu, Chang-Feng Dai, Michael Y. Chiang, and Jyh-Horng Sheu* “Nardosinane Sesquiterpenoids from the Formosan Soft Coral Lemnalia flava” J. Nat. Prod. 2011, 74, 169-174.

  35. Mei-Chun Tzeng, Su-Chih Liao, Tsu-Hsin Chang, Shih-Chi Yang, Min-Wei Weng, Hsiao-Ching Yang, Michael Y. Chiang, Zhang Kai, Jishan Wu and Chi Wi Ong* “Enforced liquid crystalline properties of dibenzo[a,c]phenazine dimer and self assembly” J. Mater. Chem., 2011, 21, 1704-1712.

  36. Su-Ling Wong, Hsun-Shuo Chang, Guei-Jane Wang, Michael Y. Chiang, Hung-Yi Huang, Chu-Huang Chen, Shiow-Chwen Tsai, Chu-Hung Lin, and Ih-Sheng Chen* “Secondary Metabolites from the Roots of Neolitsea daibuensis and Their Anti-inflammatory Activity” J. Nat. Prod. 2011, 74, 2489-2496.