Home ／About／Faculty／Professor／Dr. Po-Chiao Lin

Dr. Po-Chiao Lin
Dr. Po-Chiao Lin Professor ; Vice President for Academic Affairs
Research Areas Organic synthesis, Chemical biology, Design and synthesis of chemical probes, Glycoprotein microarray
highest education Ph. D., Taiwan International Graduate Program(Academia Sinica) and Department of Chemistry, National Tsing Hua University, Taiwan
Research room SC4023
laboratory
phone (07)5252000 分機3913
E-mail pclin@mail.nsysu.edu.tw
web https://pochiaolab.wixsite.com/pochiao
 Personal profile

學歷Education

Department of chemistry, National Taiwan Normal University, 1997-2001

Department of chemistry, National Taiwan Normal University, 2001-2003

Taiwan International Graduate Program (Academia Sinica) and Departmrnt of Chemistry, National Tsing Hua University, Taiwan, 2005-2008

經歷Experience

Research Assistant (National Defense Service), Institute of Chemistry, Academia Sinica, Taiwan.

Max-Planck Institute, GermanyDepartment of Chemical Biology (Advisor: Prof. Herbert Waldmann)

Assistant Professor, Department of Chemistry, National Sun Yat-sen University, Kaohsiung, Taiwan

Visiting Scholar in Department of Chemical and Biomedical Engineering University of Colorado at Boulder, CO, USA Host: Prof. Kristi S. Anseth

Associate Professor, Department of Chemistry, National Sun Yat-sen University, Kaohsiung, Taiwan

Selected as Emerging Investigators in RSC Analytical Methods

Organic synthesis, Chemical biology, Design and synthesis of chemical probes, Glycoprotein microarray
    著作Works
  1. Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chien-Hui Lai, Po-Chiao Lin,* Chun-Cheng Lin,*Functionalized glyconanoparticles for the study of glycobiology” in Glyco-nanotechnology as a bridge tonew medicines, ACS Symposium Series 1091, 2011, chapter 2, p15-36.
  2. P.-C. Lin, A. Kumar Adak, and C.-C. Lin*,“Fabrication and applications of glyconanomaterials.” inThe Molecular Immunology of Complex Carbohydrates-3； Eds: Albert M. Wu, Kluwer Academia/Plenum Publishers, 2011
  3. L.-S. Huang, Y.-Y. Chien, S.-H. Chen, P.-C. Lin, K.-Y. Wang, P.-H. Chou, C.-C. Lin, and Y.-J.Chen,“Nanoprobe-based Affinity Mass Spectrometry for Cancer Marker Protein Profiling”inNanomaterials for Cancer Diagnosis； Eds: Challa S. S. R. Wiley-VCH, 2007
  4. Y.-J. Chen, P.-C. Lin, C.-C. Lin, S.-H. Chen, P.-H. Chou, H.-K. Liao (2007): Mass spectrometric analysis of ligand conjugated magnetic nanoparticles, U. S. Appl. Publ. US20070054407
  5. Po-Chiao Lin, Chun-Chi Chen (2013): Method for detecting by thin-layer chromatograph mass spectrometry, Taiwan (R.O.C.) Appl. Publ. TW201443432A
  6. Po-chiao Lin, Yung-lin Yang, Yen-pin Lee (2016): Method of traceless labeling glycoproteins on surface and application thereof, U. S. Appl. Publ. US20160123988A1
  7. P.-H. Chou, S.-H. Chen, H.-K. Liao, P.-C. Lin, G.-R. Her, Alan C.-Y. Lai, J.-H. Chen, C.-C. Lin*, Y.-J. Chen* “Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma” Anal. Chem. 2005, 77, 5990–5997. html
  8. P.-C. Lin, P.-H. Chou, S.-H. Chen, H.-K. Liao, K.-Y. Wang, Y.-J. Chen, C.-C. Lin* “Ethylene Glycol-Protected Magnetic Nanoparticles for a Multiplexed Immunoassay in Human Plasma” Small, 2006, 2,485–489. html
  9. P.-C. Lin, S.-H. Ueng, M.-C. Tseng, J.-L. Ko, K.-T. Huang, S.-C. Yu, A. K. Adak, Y.-J. Chen, C.-C. Lin,* “Site-Specific Protein Modification through CuI-Catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication“ Angew. Chem. Int. Ed. 2006, 45, 4286–4290. html
  10. P.-C. Lin, M.-C. Tseng, A.-K. Su, Y.-J. Chen*, C.-C. Lin* “Functionalized Magnetic Nanoparticles for Small-Molecule Isolation, Identification, and Quantification” Anal. Chem. 2007, 79, 3401–3408. htm
  11. P.-C. Lin, S.-H. Ueng, S.-C. Yu, M.-D. Jan, A. K. Adak, C.-C. Yu, C.-C. Lin* “Surface Modification of Magnetic Nanoparticle via Cu(I)-Catalyzed Alkyne-azide [2 ＋ 3] Cycloaddition” Org. Lett. 2007, 9, 2131–2134. html
  12. T.-C. Chiu, L.-S. Huang, P.-C. Lin, Y.-C. Chen, Y.-J. Chen, C.-C. Lin, H.-T. Chang, “Nanomaterial Based Affinity Matrix-assisted Laser Desorption/Ionization Mass Spectrometry for Biomolecules and Pathogenic Bacteria” Recent patents on Nanotechnology, 2007, 1, 99–111. html
  13. C.-C. Yu, P.-C. Lin, C.-C. Lin* “Site-specific CMP-sialic acid synthetase Immobilized Magnetic Nanoparticle in the synthesis of CMP-sialic acid” Chem. Commun. 2008, 0, 1308–1310. html
  14. P.-H. Shih, J.-Y. Shiu, P.-C. Lin, C.-C. Lin, T. Veres, P. Chen “On chip sorting of bacterial cells using sugar-encapsulated magnetic nanoparticles” J. Appl. Phys. 2008, 103, 07A316. html
  15. K.-Y. Wang, S.-A. Chuang, P.-C. Lin, S.-H. Chen, L.-S. Huang, C.-C. Lin, and Y.-J. Chen* “Multiplexed Immunoassay: Quantitation and Profiling of Serum Biomarkers Using Magnetic Nanoprobes and MALDI-TOF MS” Anal. Chem. 2008, 80, 6159–6167. html
  16. P.-C. Lin, H.-T. Wu, K.-Y. Wang, Y.-J. Chen, C.-C. Lin, “Development and Application of Functionalized Nanoparticles on Mass Spectrometry for the Analysis of Target Biomolecules” Instruments Today, 2008, 29, 68. (in Taiwan) html
  17. P.-C. Lin, S.-H. Chen, M.-L. Chen, A. Kumar Adak, Y.-J. Chen* and C.-C. Lin*, “Fabrication of Oriented Antibody-Conjugated Magnetic Nanoprobes and Their Immunoaffinity Application” Anal. Chem. 2009, 81, 8774–8782 html
  18. P.-C. Lin, A. K. Adak, S.-H. Ueng, L.-D. Huang, K.-T. Huang, C.-C. Lin*, “ DAST-Mediated Regioselective Anomeric Group Migration in Saccharides” J. Org. Chem. 2009, 74, 4041–4048.hmtl
  19. P.-C. Lin, D. Weinrich, H. Waldmann “Protein Biochips: Oriented Surface Immobilization of Proteins” Marcromol. Chem. Phys. 2010, 211, 136–144. hmtl
  20. D. Weinrich, P.-C. Lin, P. Jonkheijm, H. Schröder, C. M. Niemeyer, K. Alexandrov, H. Waldmann. “Oriented Immobilization of Farnesylated Proteins by Thiol-Ene Reaction” Angew. Chem. Int. Ed. 2010, 49,1252–1257. html
  21. M.-C. Tseng, R. Obena, Y.-W. Lu, P.-C. Lin, P.-Y. Lin, Y.-S. Yen, J.-T. Lin, L.-D. Huang, K.-L. Lu, L.-L. Lai, C.-C. Lin, Y.-J. Chen “Dihydrobenzoic Acid Modified Nanoparticle as a MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures” J. Am. Soc. Mass Spectrom, 2010, 11, 1930–1939.html
  22. W.-C. Chen, P.-C. Lin, C.-H. Chen, C.-T. Chen “Modulation of Photoswitching Profiles by 10,11-Dialkoxymethyl Substituents in C2-Symmetric Dibenzosuberane-Based Helicenes” Chem. Eur. J., 2010, 43, 12822–12830. html
  23. H.-T. Wu, C.-C. Hsu, C.-F. Tsai, P.-C. Lin, C.-C. Lin* and Y.-J. Chen,” Nanoprobe based Immobilized Metal Affinity Chromatography for Enhanced Enrichment of Multiply Phosphorylated Peptides” Proteomics, 2011, 11, 2639–2653. html
  24. R.-P. Obena, P.-C. Lin, Y.-W. Lu, I.-C. Li, F. Del Mundo, S. D. Arco, G.M. Nuesca, C.-C. Lin*, Y.-J. Chen, “Iron oxide nanomatrix facilitating metal ionization in matrix-assisted laser desorption/ionization mass spectrometry.” Anal. Chem. 2011, 83, 9337–9343. html
  25. L. Yi, Y.-X. Chen, P.-C. Lin, Schröder H, C.-M. Niemeyer, Y.-W. Wu, R.-S. Goody, G. Triola*, H. Waldmann* “Direct immobilization of oxyamine-modified proteins from cell lysates.” Chem. Commun. 2012, 48, 10829-10831. html
  26. P.-C. Lin*, C.-C. Yu, H.-T. Wu, Y.-W. Lu, C.-L. Han, A.-K. Su, Y.-J. Chen*, C.-C. Lin* “A Chemically Functionalized Magnetic Nanoplatform for Rapid and Specific Biomolecular Recognition and Separation” Biomacromolecules, 2013, 14, 160-168. html (SCI impact factor:5.738； 5-Year IF:5.941, ranking: 6/87 (Q1) in polymer science)
  27. Y.-L. Yang, B. Rajagopal, C.-F. Liang, C.-C. Chen, H.-P. Lai, C.-H. Chou, Y.-P. Lee, Y.-L. Yang, J.-W. Zeng, C.-L. Ou, P.-C. Lin* “Chemoselective Synthesis of Aryl Carboxamido Sulfonic Acid Derivatives” Tetrahedron, 2013, 69, 2640–2646.html (SCI impact factor:2.377； 5-Year IF:2.255, ranking: 23/57 (Q2) in chemistry, organic)
  28. C.-C. Chen, Y.-L. Yang, C.-L. Ou, C.-H. Chou, C.-C. Liaw, P.-C. Lin* “Direct Monitoring of Chemical Transformations by Combining Thin Layer Chromatography with Nanoparticle-assisted Laser Desorption /Ionization Mass Spectrometry” Analyst, 2013, 138, 1379–1385. html SCI impact factor:3.864； 5-Year IF:3.791, ranking:11/80 (Q1) in chemistry, analytical)
  29. Y.-W. Lu, C.-W. Chien, P.-C. Lin, L.-D. Huang, C.-Y. Chen, S.-W. Wu, C.-L. Han, K.-H. Khoo, C.-C Lin.*, Y.-J. Chen* “BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichmentof Glycoproteins” Anal. Chem. 2013, 85, 8268-8276. html (SCI impact factor:6.042； 5-Year IF:6.035, ranking:4/80 (Q1) in chemistry, analytical)
  30. S. Hsieh*, S.-L. Hsieh, C.-W. Hsieh, P.-C. Lin, C.-H. Wu “Label-free glucose detection using cantilever sensor technology based on gravimetric detection principles” J. Anal. Methods. Chem. 2013, Article ID 687265.html (SCI impact factor:1.262； 5-Year IF:1.722, ranking:75/128 (Q3) in engineering, civil)
  31. C.-C. Chen, B. Rajagopal, X.-Y. Liu, K.-L. Chen, Y.-C. Tyan, F. Lin, P.-C. Lin* “A mild removal of Fmoc group using sodium azide” Amino Acids, 2014, 46, 367–374.html ； 5-Year 2.906SCI impact factor:(:2.946, ranking:148/292 (Q3) in biochemistry ＆ molecular biology)IF
  32. Y.-L. Yang, Y.-P. L., Y.-L. Yang, P.-C. Lin* “Traceless Labeling of Glycoproteins and Its Application to the Study of Glycoprotein-protein Interact” ACS Chem. Biol. 2014, 9, 390-397. html (SCI impact factor:4.592； 5-Year IF:4.794, ranking: 57/292 (Q1) in biochemistry ＆ molecular biology)
  33. B. Rajagopal, Y.-Y. Chen, C.-C. Chen, X.-Y. Liu, H.-R. Wang, P.-C. Lin* “Cu(I)-Catalyzed Synthesis of Dihydropyrimidin-4-ones toward the Preparation of β- and β3-Amino Acid Analogues” J. Org. Chem. 2014, 79, 1254–1264. html (SCI impact factor:4.805； 5-Year IF:4.313, ranking: 9/57 (Q1) in chemistry, organic)
  34. B. Rajagopal, C.-H. Chou, C.-C. Chung, P.-C. Lin* “Synthesis of Substituted 3-Indolylimines and Indole-3-carboxaldehydes by Rhodium (II)-Catalyzed Annulation.” Org. Lett. 2014, 16, 3752–3755. html (SCI impact factor:6.492； 5-Year IF:5.778, ranking: 3/57 (Q1) in chemistry, organic)
  35. C.-C. Chen, P.-C. Lin* “Monitoring of chemical transformations by mass spectrometry.” Anal. Methods, 2015, 7, 6947–6959. html (SCI impact factor:2.073； 5-Year IF:2.000 , ranking: 52/133 (Q2) in food science ＆ technology)
  36. Y.-Y. Chen, K.-L. Chen, Y.-C. Tyan, C.-F. Liang, P.-C. Lin* “Synthesis of substituted 3-methylene-2,3-dihydrobenzofurans and 3-methylbenzofurans by rhodium (II)-catalyzed annulation” Tetrahedron, 2015, 71, 6210-6218. html (SCI impact factor:2.377； 5-Year IF:2.255, ranking : 23/57 (Q2) in Chemistry, organic)
  37. C.-H. Chou, Y.-Y. Chen, B. Rajagopal, H.-C. Tu, K.-L. Chen, S.-F. Wang, C.-F. Liang, Y.-C. Tyan, and P.-C. Lin* “Thermally Induced Denitrogenative Annulation for the Synthesis of Dihydroquinolinimines and Chroman-4-imines” Chem. Asian J., 2016, 11, 757–765.html (SCI impact factor:3.692； 5-Year IF:3.497, ranking : 51/171 (Q1) in Chemistry, multidisciplinary)
  38. C.‐C. Chen, S.‐F. Wang, Y.‐Y. Su, Y. A. Lin, P.‐C. Lin* “Copper(I)‐Mediated Denitrogenative Macrocyclization for the Synthesis of Cyclic α3β‐Tetrapeptide Analogues” Chem. Asian J., 2017, 12, 1326–1337 html (SCI impact factor:3.692； 5-Year IF:3.497, ranking: 51/171 (Q1) in Chemistry, multidisciplinary)
  39. C.-H. Chou, B. Rajagopal, C.-F. Liang, K.-L. Chen, D.-Y. Jin, H.-Y. Chen*, H.-C. Tu, Y.-Y. Shen, P.-C. Lin* “Synthesis and Photophysical Characterization of 2,3-Dihydroquinolin-4-imines: New Fluorophores with Color-Tailored Emission.” Chem. Eur. J., 2018, 24, 1112–1120.html (SCI impact factor:5.160； 5-Year IF:4.950, ranking: 37/171 (Q1) in Chemistry, multidisciplinary)
  40. C.-H. Chou, P.-C. Lin* “Glycan-Directed Grafting-from Polymerization of Immunoglobulin G: Site-Selectively Modified IgG-Polymer Conjugates with Preserved Biological Activity” Biomacromolecules, 2018, 19, 3086–3095. html (SCI impact factor:5.738； 5-Year IF:5.941, ranking: 6/87 (Q1) in polymer science)
  41. K.-K. Yu, W.-B. Tseng, M.-J. Wu, A. S. K. K. Alagarsamy, W.-L. Tseng*, P.-C. Lin* “Polyadenosine- based fluorescent probe for reversible pH sensing based on protonated adenine-adenine base pairs: Applications to sensing of enzymesubstrate system and enzymatic logic gates” Sens. actuators. B Chem. 2018, 273, 681–688. html (SCI impact factor:5.667； 5-Year IF:5.118, ranking: 2/61 (Q1) in instrument ＆ instrumentation)
  42. S.-C. Tang, H. Ma, H.-C. Tu, H.-R. Wang, P. C. Lin* and Kristi S. Anseth* “Adaptable Fast Relaxing Boronate - Based Hydrogels for Probing Cell Matrix Interactions” Adv. Science 2018, 1800638. html (SCI impact factor:12.441； 5-Year IF:12.551, ranking: 13/171 (Q1) in chemistry, multidisciplinary)
  43. Y.-W. Luo, C.-H. Chou, P.-C. Lin,* and C.-M. Chiang* " Photochemical Synthesis of Azoarenes from Aryl Azides on Cu(100): A Mechanism Unraveled" J. Phy. Chem. C 2019, 123, 12195.
  44. H.-C. Tu, Y.-P. Lee, X.-Y. Liu, C.-F. Chang, and P.-C. Lin* "Direct Screening of Glycan Patterns from Human Sera: A Selective Glycoprotein Microarray Strategy" ACS Appl. Bio Mater. 2019, 2, 1286.
  45. J.-G. You, D.-Y. Jin, W.-B. Tseng, W.-L. T*, P.-C. Lin* "Gold(I)‐Thiolate Oligomers for Catalytic Hydrogenation of Nitroaromatics in Aqueous and Organic Medium" ChemCatChem. 2020, 12, 4558-4567 html
  46. C.- H. Chou, C.- Y. Wu, C.- L. Chen, J.- Q Zhou, Y.- C. Kao, H.-Y. Chen, P.- C. Lin* "In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence" Chem. Comm. 2020, Advance Article, DOI : 10.1039/ d0cc03090b html
    專利Patents