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吳明忠

吳明忠 特聘教授兼理學院院長 
研究領域 過渡金屬催化之有機反應、設計與合成新的抗癌藥物、天然物之全合成研究
最高學歷 美國Clemson大學化學博士
研究室 C6001
實驗室 C6004
電話 (07)5252000 分機3914
E-mail mijuwu@faculty.nsysu.edu.tw
個人網頁 https://chem2.nsysu.edu.tw/var/file/180/1180/img/780/mj_wu_c..htm
 個人簡介

學歷Education

美國Clemson大學化學博士 (1987)

清華大學化學系學士(1979)

經歷Experience

中山大學化學系教授 (2008-迄今)

高雄醫學大學醫藥暨應用化學系教授 (1994 -2008)

高雄醫學大學學生事務處學務長 (2000 -2006)

高雄醫學大學學生事務處生涯規劃暨就業輔導組組長 (1994-2000)

高雄醫學大學醫藥暨應用化學系副教授 (1990 - 1994)

SmithKline Beechem Pharmaceuticals博士後研究員 (1989 - 1990)

The Pennsylvania State University 博士後研究員 (1987 - 1989)

2004年高雄醫學大學教學優良教師

2004年高雄醫學大學校友文教基金會優秀論文獎

2004年高雄醫學大學研究傑出教師獎(RPI最佳獎;整合型計畫總主持人獎)

2002年高雄醫學大學生命科學院研究傑出獎

2002年高雄醫學大學教學優良教師

2001年高雄醫學大學生命科學院研究傑出獎

1999年訓育委員會訓輔工作績優人員獎

1997年高雄醫學院優良教師

1991 - 2000年國科會甲等研究獎勵

1.過渡金屬催化之有機反應

2. 設計與合成新的抗癌藥物

3. 天然物之全合成研究

    著作Works
  1. Chih-Jyun-Tsai,Chin-Chau-Chen,Chih-Wei,Tsai,Ming-Jung Wu* Base-Mediated Cyclization Reaction of 2-(5-Hydroxy-1-pentynyl)benzonitriles To 4-Amino-2,3-dihydronaphtho[2,3-b]furanes and Synthesis of Furanonaphthoquinones“J. Org. Chem 2016,81卷,9期,3882-3889”
  2. Hung-Chou Wu,Jean-Ho Chu*,Chin-Wei Li,Long-Chih Hwang, Ming-Jung Wu* Palladium-Catalyzed Regioselective Arylation of Pyrazolo[1,5-α]pyridines via C-H Activation and Synthetic Applications on P38 Kinase Inhibitors“Organometallics 2016,35卷02期,288-300”
  3. CLi-Lan Wei,Li-Mei Wei,Po-Yang Lin,Chin-Chau Chen, Wen-Bin Pan*,Ming-Jung Wu* Palladium(0)-catalyzed 5-exo-dig O-cyclization/coupling of ethyl 3-(2-alkynylphenyl)-3-oxopropanoates with aryl iodides to 1,3-dihydroisobenzofurans“Tetrahedron Lett 2015,56卷,47期,6629-6632”
  4. Jean-ho Chu,Shih-Tien Chen,Meng-Fan Chiang,and Ming-Jung Wu* Palladium-Catalyzed Direct Ortho Aroylation of 2-Phenoxypyridines with Aldehydes and Catalytic Mechanism Investigation“Organometallics 2015,34卷05期,953-966”
  5. Chin-Chau Chen,Chu-Mei Chen, and Ming-Jung Wu* Transition Metal-Catalyzed Cascade Cyclization of Aryldiynes to Halogented Benzo[b]naphtho[2,1-d]thiophene Derivatives“J. Org. Chem 2014,79卷10期,4704-4711”
  6. Jean-Ho Chu,Hao-Ping Huang,Wen-Ting Hsu,Shih-Tien Chen and Ming-Jung Wu* Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via C-H Activation/C-C Coupling and Synthetic Applications“Organometallics 2014,33卷05期,1190-1204”
  7. Jean-Ho Chu*, Wen-Ting Hsu, Yi-Hua Wu, Meng-Fan Chiang, Nan-Hai Hsu, Hao-Ping Huang, and Ming-Jung Wu* Substituent Electronic Effects Direct Intramolecular C-N Cyclization of N-(Biphenyl)pyridine-2-amines Induced by Hypervalent Iodine(III) Reagents“J. Org. Chem 2014,79卷23期,11395-11408”
  8. Chuang DW, Mohamed ES, Chen CC, Chung YM, Brave BD, Wu MJ, Chang FR, Wu YC* Synthesis of 1,5-diphenylpent-3-en-1-yne derivatives utilizing an aqueous B-alkyl Suzuki cross coupling reaction.“Tetrahedron Lett 2013,54卷,38期,5162-5166”
  9. Cheng-Han Lin, Chin-Chau Chen, and Ming-Jung Wu* Mercury(II)-Catalyzed Cyclization of 2-Alkynylphenyl Alkyl Sulfoxides Provides 3-Acylbenzo[b]thiophenes.”Chem.Eur. J. 2013,19卷08期,2578-2581”
  10. Yu-Hsiang Lo , Ying-Ting Lin , Yu-Peng Liu , Tsai-Hui Duh , Pei-Jung Lu, Ming-Jung Wu* Design, synthesis, biological evaluation and molecular modeling studies of 1-aryl-6-(3,4,5-trimethoxyphenyl)-3(Z)- hexen-1,5-diynes as a new class of potent antitumor agents“Eur. J Med Chem 2013,62卷,526-533”
  11. Jean-Ho Chu, Chung-Chiu Wu, Deng-Hsiang Chang, Ya-Ming Lee, and Ming-Jung Wu* Direct Ortho Arylation of 9 (Pyridin-2-yl)9H carbazoles Bearing a Removable Directing Group via Palladium(II)-Catalyzed C?H Bond Activation“Organometallics 2013,32卷01期,272-282”
  12. Wen-Bin Pan, Chin-Chau Chen, Li-Lan Wei, Li-Mei Wei, Ming-Jung Wu* One-pot synthesis of 2,20-bisbenzofurans using cuprous chloride as a catalyst“Tetrahedron Lett 2013,54卷21期,2655-2657”
  13. Hung-Chou Wu, Chia-Wen Yang, Long-Chih Hwang and Ming-Jung Wu* Au(I)-catalyzed and iodine-mediated cyclization of enynylpyrazoles to provide pyrazolo[1,5-a]pyridines“Org. Biomol. Chem. 2012,10卷33期,6640-6648”
  14. Jean-Ho Chu,Pi-Shan Lin,Ya-Ming Lee,Wei-Ting Shen,Ming-Jung Wu* ”Palladium(II)-Catalyzed One-Pot Syntheses of 9-(Pyridin-2-yl)-9H-carbazoles through a Tandem C-H Activation/C-X(X=C or N)Formation Process”.“Chem. Eur. J 2011,17卷48期,13613-13620”
  15. Chin-Chau Chen, Shyh-Chyun Yang, Ming-Jung Wu* ”Iodine-Mediated Cascade Cyclization of Enediynes to Iodinated Benzo[a]carbazoles”.“J. Org. Chem 2011,76卷24期,10269-10274”
  16. H. C. Wu, L. C. Hwang, M. J. Wu,* “Copper-Mediated Cyclization Reaction of Enediynones with Hydrazine Provides Pyrazolo[1,5-a]pyridines”“Org. Biomol. Chem. 2011, 9卷03期, 670-672”
  17. C. C. Chen, L. Y. Chin, S. C. Yang, M. J. Wu,* “Synthetic Development and Mechanistic Study on Pd(II)-Catalyzed Cyclization of Enediynes to Benzo[a]carbazoles”“Org. Lett. 2010, 12卷24期, 5652.-5655”
  18. J. H. Chu, P. S. Lin, M. J. Wu,* “Palladium(II)-Catalyzed Ortho Arylation of 2-Phenoxypyridines with Potassium Aryltrifluoroborates via C-H Functionalization”“Organometallics 2010, 29卷18期, 4058-4065”
  19. C. W. Tsai, S. C. Yang, Y. M. Liu, M. J. Wu* “Microwave-assisted Cycloaddition of 2-Alkynylbenzonitriles with Sodium Azides: Selective Synthesis of Tetrazolo[5,1-a]pyridines and 4,5-Disubstituted-2H-1,2,3-triazoles”“Tetrahedron 2009, 65, 8367-8372”
  20. J. H. Chu, S. L. Tsai, M. J. Wu* “Palladium(II)-Catalyzed ortho Arylation of 2-Phenylpyridines with Potasium Aryltrifluoroborates by C-H Functionalization”“Synthesis 2009, 3757-3764.”
  21. J. H. Chu, Y. J. Chen, M. J. Wu* “Mild Oxidation of Diarylacetylenes to 1,2-Diketones Using Oxone in Trifluoroacetic acid”“Synthesis, 2009, 2155-2162.”
  22. C. Y. Kuo,* M. J. Wu “The Synthesis of N-Phenoxyethyl-1-substituted-1,2,3,4-tetrahydroisoquinolines and Their 1-adrenoceptor Blocking Activity”“Eur. J. Med. Chem. 2009, 44, 1271-1277”
  23. K. F. Tseng, C. F. Lin, Y. H. Lo, Y. L. Hu, L. Y. Chen, S. H. Yang, S. R. Lin, L. S. Chang, M. J. Wu* “Synthesis and Biological Evalution of Novel Symmetry Bis-enediynes”“Eur. J. Med. Chem. 2009, 44, 35-41.”
  24. Y. S. Tu, T. H. Duh, C. Y. Tseng, Y. T. Lin, Y. H. Lo, Y. L. Hu, C. H. Chen, C. M. Chien, S. H. Yang, Lin, S. R. S. C. Yang, M. J. Wu* “1-(2-((Z)-6-(2-Trifluoromethylphenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one as a New Potent Apoptosis Agent”“Bioorg. Med. Chem. 2009, 17, 7412-7417.”
  25. W. P. Hu, J. J. Liang, C. L. Kao, Y. C. Chen, C. Y. Chen, F. Y. Tsai, M. J. Wu, L. S. Chang, Y. L. Chen, J. J. Wang* “Synthesis and Antitumor Activity of Novel Enediyne-linked Pyrrolo[2,1-c][1,4]benzodiazepine hybrids”“Bioorg. Med. Chem. 2009, 17, 1172-1180.”
    專利Patents